Transplanted bone marrow-derived cell migration into periodontal tissues and cell differentiation

Rina Muraoka, Hidetsugu Tsujigiwa, Keisuke Nakano, Naoki Katase, Ryo Tamamura, Mihoko Tomida, Norimasa Okafuji, Hitoshi Nagatsuka, Toshiyuki Kawakami

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


We examined the transplanted bone marrow-derived cell migration into periodontal tissues. Bone marrow cells from green fluorescent protein (GFP) transgenic mice were transplanted. The immunohistochemistry (IHC) revealed that GFP-positive cells were detected in the periodontal tissues. The GFP-positive cells histopathologically differentiated into some cell types. The fluorescence IHC and TRAP staining techniques demonstrated these cells were detected as osteoclasts and macrophages. Furthermore, GFP-positive cells gathered adjacent blood vessels. The data suggest that GFP-positive bone marrow-derived cell migrate into periodontal tissues and differentiate periodontal tissue component-cells.

Original languageEnglish
Pages (from-to)301-306
Number of pages6
JournalJournal of Hard Tissue Biology
Issue number4
Publication statusPublished - 2011


  • Bone marrow-derived cells
  • Fibroblasts
  • Green fluorescent protein (GFP)
  • Macrophages
  • Osteoclasts
  • Periodontal tissues

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Biochemistry
  • Biomaterials
  • Orthopedics and Sports Medicine
  • Dentistry(all)
  • Cell Biology


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