TY - JOUR
T1 - Transport of trace elements in lenses of normal and hereditary cataract UPL rats
AU - Nabekura, Tomohiro
AU - Minami, Takeshi
AU - Hirunuma, Rieko
AU - Enomoto, Shuichi
AU - Tomohiro, Masayuki
AU - Ito, Yoshimasa
AU - Kitagawa, Shuji
N1 - Funding Information:
We are grateful to the staff of the RIKEN Accelerator Research Facility for their cooperation in the heavy-ion irradiation. This work was supported by a Grant-in-Aid for Encouragement of Young Scientist from the Ministry of Education, Culture, Sports, Science and Technology of Japan (T.N.).
PY - 2003/9/30
Y1 - 2003/9/30
N2 - The multitracer technique was applied to the determination of the uptake of trace elements in the lenses of normal and hereditary cataract UPL rats to investigate the transport mechanisms of trace elements during cataract development. Be, Na, Sc, V, Cr, Mn, Fe, Co, Zn, As, Se, Rb, Sr, Y, Zr, Tc, Ru and Rh accumulate in normal and UPL cataract rat lenses. The rates of uptake of trace elements differ among species and also differ between normal and UPL rat lenses. The uptakes of V and Sr are greater in normal rat lenses, while the uptakes of Mn and Co are greater in UPL rat lenses. High concentrations of Zn are transported into normal rat lenses in comparison with other elements. However, the uptake of Se was highest in the lenses of UPL cataract rats. In addition, the difference in Se uptake between the normal and UPL rat lenses was greatest among the tested trace elements. The present study suggests that the transport characteristics of trace elements are different in the lenses of normal and UPL cataract rats. The different transport characteristics of trace elements in the lenses of normal and UPL cataract rats, especially the higher accumulation of Se in UPL rat lenses, may be implicated in cataract development.
AB - The multitracer technique was applied to the determination of the uptake of trace elements in the lenses of normal and hereditary cataract UPL rats to investigate the transport mechanisms of trace elements during cataract development. Be, Na, Sc, V, Cr, Mn, Fe, Co, Zn, As, Se, Rb, Sr, Y, Zr, Tc, Ru and Rh accumulate in normal and UPL cataract rat lenses. The rates of uptake of trace elements differ among species and also differ between normal and UPL rat lenses. The uptakes of V and Sr are greater in normal rat lenses, while the uptakes of Mn and Co are greater in UPL rat lenses. High concentrations of Zn are transported into normal rat lenses in comparison with other elements. However, the uptake of Se was highest in the lenses of UPL cataract rats. In addition, the difference in Se uptake between the normal and UPL rat lenses was greatest among the tested trace elements. The present study suggests that the transport characteristics of trace elements are different in the lenses of normal and UPL cataract rats. The different transport characteristics of trace elements in the lenses of normal and UPL cataract rats, especially the higher accumulation of Se in UPL rat lenses, may be implicated in cataract development.
KW - Cataract
KW - Crystalline lens
KW - Multitracer
KW - Selenium
KW - Trace element
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U2 - 10.1016/S0300-483X(03)00261-0
DO - 10.1016/S0300-483X(03)00261-0
M3 - Article
C2 - 12965125
AN - SCOPUS:0142056981
SN - 0300-483X
VL - 191
SP - 227
EP - 232
JO - Toxicology
JF - Toxicology
IS - 2-3
ER -