Trends of preterm birth and low birth weight in Japan: A one hospital-based study

Takashi Yorifuji, Hiroo Naruse, Saori Kashima, Takeshi Murakoshi, Tsuguhiko Kato, Sachiko Inoue, Hiroyuki Doi, Ichiro Kawachi

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)


Background: The proportions of preterm birth (PTB, ie., delivered before 37 gestational weeks) and low birth weight (LBW, ie., birth weight less than 2500 g at delivery) have been rising in developed countries. We sought to examine the factors contributing to the rise in Japan, with particular focus on the effects of obstetric interventions.Methods: We used a database maintained by one large regional hospital in Shizuoka, Japan. We restricted the analysis to mothers who delivered live singleton births from 1997 to 2010 (n = 19,221). We assessed the temporal trends in PTB and LBW, then divided the study period into four intervals and compared the proportions of PTB and LBW. We also compared the newborns' outcomes between the intervals.Results: PTB, in particular medically indicated PTB, increased considerably. The increase was largely explained by changes in caesarean sections. The neonatal outcomes did not worsen, and instead the Apgar scores and proportions requiring neonatal intensive care unit (NICU) admission improved. In particular, the risks of NICU admission in the interval from 2007 to 2010 were decreased among all births [odds ratio (OR): 0.84; 95% confidence interval (CI): 0.75, 0.95] and medically indicated births (OR: 0.44; 95% CI: 0.29, 0.68) compared with the interval from 1997 to 2000.Conclusions: Despite the increases in PTB as well as LBW, the present study suggests benefits of obstetric interventions. Rather than simple categorization of PTB or LBW, indicators such as perinatal mortality or other outcomes may be more appropriate for evaluation of perinatal health in developed countries.

Original languageEnglish
Article number162
JournalBMC Pregnancy and Childbirth
Publication statusPublished - Dec 26 2012


  • Caesarean section
  • Low birth weight
  • Pregnancy
  • Preterm birth
  • Reproductive health

ASJC Scopus subject areas

  • Obstetrics and Gynaecology


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