Tumor-infiltrating lymphocytes can be used to screen for lynch syndrome - A case report

Kohji Tanakaya, Nobuhiko Kanaya, Kunitoshi Shigeyasu, Tomoyoshi Kunitomo, Hideki Aoki, Hitoshi Takeuchi, Rie Yamasaki

Research output: Contribution to journalArticlepeer-review


Lynch syndrome is an inherited syndrome associated with the development of colorectal and various other cancers. A 65-year-old male underwent a laparoscopic-assisted right hemi-colectomy for ascending colon cancer (cStage II). Histologically, his tumor was diagnosed as a poorly differentiated adenocarcinoma. Lymphocytic reactions, such as tumor-infiltrating lymphocytes (TIL), and Crohn's-like reactions, were observed. Genetic testing revealed the presence of a pathogenic mutation in the MLH1. In the Lynch syndrome, the most frequently observed findings include the accumulation of mutations, and an early onset of familial colon cancer. Although the case presented here did not show the typical clinical findings of Lynch syndrome, histological examination of the lymphocytic reactions proved useful for screening for Lynch syndrome. Herein, we establish the important role of the pathologist in alerting the clinician to the possibility of Lynch syndrome when the findings of TIL and Crohn's-like reactions are detected.

Original languageEnglish
Pages (from-to)1602-1604
Number of pages3
JournalJapanese Journal of Cancer and Chemotherapy
Issue number12
Publication statusPublished - Nov 2014
Externally publishedYes


  • Lynch syndrome
  • Screening
  • Tumor-infiltrating lymphocyte

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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