Two antinematodal phenolics from Knema hookeriana, a Sumatran rainforest plant

Yohannes Alen, Shuhei Nakajima, Teruhiko Nitoda, Naomichi Baba, Hiroshi Kanzaki, Kazuyoshi Kawazu

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)


The activity-guided chromatographic purification of the methanol extract of Knema hookeriana, using pine wood nematodes Bursaphelenchus xylophilus has successfully led to the isolation and characterization of two phenolic antinematodal compounds with minimum effective dose (MED) of 4.5 and 20 μg/cotton ball (μg/bl.) or 0.018 and 0.073 μM/cotton ball (μM/bl.), respectively. Based on their chemical and spectral properties, these compounds were determined to be 3-undecylphenol (1) and 3-(8Z-tridecenyl)-phenol (2). These compounds were isolated for the first time from this species, and 2 seems to be a novel compound.

Original languageEnglish
Pages (from-to)300-303
Number of pages4
JournalZeitschrift fur Naturforschung - Section C Journal of Biosciences
Issue number3-4
Publication statusPublished - 2000


  • Antinematodal Compounds
  • Bursaphelenchus xylophilus
  • Knema hookeriana

ASJC Scopus subject areas

  • General Biochemistry,Genetics and Molecular Biology


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