Two cases of cancer-associated retinopathy combined with small-cell lung cancer

Yuichi Sakamori; Young Hak Kim; Chiyuki Okuda; Yosuke Togashi; Daisuke Kinose; Katsuhiro Masago; Tadashi Mio; Akihito Uji; Michiaki Mishima

doi:10.1093/jjco/hyr025

Two cases of cancer-associated retinopathy combined with small-cell lung cancer

Yuichi Sakamori, Young Hak Kim, Chiyuki Okuda, Yosuke Togashi, Daisuke Kinose, Katsuhiro Masago, Tadashi Mio, Akihito Uji, Michiaki Mishima

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

Cancer-associated retinopathy is a rare paraneoplastic syndrome that is often associated with small-cell lung cancer. It is caused by an autoantibody to the 23 kDa photoreceptor protein, recoverin. A small number of reports have described effective treatment for the disease. We report two cases of cancer-associated retinopathy with small-cell lung cancer whose visual symptom preceded the diagnosis of cancer. Their visual acuity and visual field were slightly improved after steroid and anticancer therapy. Steroid therapy was effective, although the period from visual symptom onset to therapy was comparative longer. When cancer-associated retinopathy is suspected, a comparatively large quantity of steroids and anticancer treatment should be combined immediately.

Original language	English
Article number	hyr025
Pages (from-to)	669-673
Number of pages	5
Journal	Japanese journal of clinical oncology
Volume	41
Issue number	5
DOIs	https://doi.org/10.1093/jjco/hyr025
Publication status	Published - May 2011
Externally published	Yes

Keywords

Cancer-associated retinopathy
Corticosteroid
Paraneoplastic syndrome
Recoverin
Small-cell lung cancer

ASJC Scopus subject areas

Oncology
Radiology Nuclear Medicine and imaging
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/jjco/hyr025

Cite this

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title = "Two cases of cancer-associated retinopathy combined with small-cell lung cancer",

abstract = "Cancer-associated retinopathy is a rare paraneoplastic syndrome that is often associated with small-cell lung cancer. It is caused by an autoantibody to the 23 kDa photoreceptor protein, recoverin. A small number of reports have described effective treatment for the disease. We report two cases of cancer-associated retinopathy with small-cell lung cancer whose visual symptom preceded the diagnosis of cancer. Their visual acuity and visual field were slightly improved after steroid and anticancer therapy. Steroid therapy was effective, although the period from visual symptom onset to therapy was comparative longer. When cancer-associated retinopathy is suspected, a comparatively large quantity of steroids and anticancer treatment should be combined immediately.",

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author = "Yuichi Sakamori and Kim, {Young Hak} and Chiyuki Okuda and Yosuke Togashi and Daisuke Kinose and Katsuhiro Masago and Tadashi Mio and Akihito Uji and Michiaki Mishima",

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language = "English",

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T1 - Two cases of cancer-associated retinopathy combined with small-cell lung cancer

AU - Sakamori, Yuichi

AU - Kim, Young Hak

AU - Okuda, Chiyuki

AU - Togashi, Yosuke

AU - Kinose, Daisuke

AU - Masago, Katsuhiro

AU - Mio, Tadashi

AU - Uji, Akihito

AU - Mishima, Michiaki

PY - 2011/5

Y1 - 2011/5

N2 - Cancer-associated retinopathy is a rare paraneoplastic syndrome that is often associated with small-cell lung cancer. It is caused by an autoantibody to the 23 kDa photoreceptor protein, recoverin. A small number of reports have described effective treatment for the disease. We report two cases of cancer-associated retinopathy with small-cell lung cancer whose visual symptom preceded the diagnosis of cancer. Their visual acuity and visual field were slightly improved after steroid and anticancer therapy. Steroid therapy was effective, although the period from visual symptom onset to therapy was comparative longer. When cancer-associated retinopathy is suspected, a comparatively large quantity of steroids and anticancer treatment should be combined immediately.

AB - Cancer-associated retinopathy is a rare paraneoplastic syndrome that is often associated with small-cell lung cancer. It is caused by an autoantibody to the 23 kDa photoreceptor protein, recoverin. A small number of reports have described effective treatment for the disease. We report two cases of cancer-associated retinopathy with small-cell lung cancer whose visual symptom preceded the diagnosis of cancer. Their visual acuity and visual field were slightly improved after steroid and anticancer therapy. Steroid therapy was effective, although the period from visual symptom onset to therapy was comparative longer. When cancer-associated retinopathy is suspected, a comparatively large quantity of steroids and anticancer treatment should be combined immediately.

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KW - Corticosteroid

KW - Paraneoplastic syndrome

KW - Recoverin

KW - Small-cell lung cancer

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Two cases of cancer-associated retinopathy combined with small-cell lung cancer

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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