Two cases of cancer-associated retinopathy combined with small-cell lung cancer

Yuichi Sakamori, Young Hak Kim, Chiyuki Okuda, Yosuke Togashi, Daisuke Kinose, Katsuhiro Masago, Tadashi Mio, Akihito Uji, Michiaki Mishima

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)


Cancer-associated retinopathy is a rare paraneoplastic syndrome that is often associated with small-cell lung cancer. It is caused by an autoantibody to the 23 kDa photoreceptor protein, recoverin. A small number of reports have described effective treatment for the disease. We report two cases of cancer-associated retinopathy with small-cell lung cancer whose visual symptom preceded the diagnosis of cancer. Their visual acuity and visual field were slightly improved after steroid and anticancer therapy. Steroid therapy was effective, although the period from visual symptom onset to therapy was comparative longer. When cancer-associated retinopathy is suspected, a comparatively large quantity of steroids and anticancer treatment should be combined immediately.

Original languageEnglish
Article numberhyr025
Pages (from-to)669-673
Number of pages5
JournalJapanese journal of clinical oncology
Issue number5
Publication statusPublished - May 2011
Externally publishedYes


  • Cancer-associated retinopathy
  • Corticosteroid
  • Paraneoplastic syndrome
  • Recoverin
  • Small-cell lung cancer

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research


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