Two cases of corneal perforation after oral administration of nonsteroidal anti-inflammatory drugs: Oral NSAID-induced corneal damage

PURPOSE. To report 2 cases of corneal perforation associated with the use of oral nonsteroidal antiinflammatory drugs (NSAIDs). METHODS. In a 62-year-old woman and a 79-year-old woman, corneal perforation occurred after 7 days and 5 months of oral NSAIDs administration, respectively. RESULTS. After NSAIDs were discontinued, the cornea epithelialized and the anterior chamber formed within 14 and 10 days, respectively. CONCLUSIONS. It is well known that topical NSAIDs cause corneal perforation. Observations in the present cases suggest that the oral administration of NSAIDs may also cause corneal damage, and hence, medical professionals should consider the risk of damage to the cornea when administering these drugs orally.