Two cases of dural metastasis of breast cancer

Seiji Yoshitomi, Hisashi Tsuji, Yuko Abe, Kazuaki Miyahara, Hajime Kashima, Takeshi Kurosaki, Masatoshi Kuroda, Toshihisa Yamano, Shoji Takagi, Eiji Ikeda, Ryuji Hirai, Shigeharu Moriyanna

Research output: Contribution to journalArticlepeer-review


The first case of dural metastasis occurred in a 60s years old woman, who presented with bone metastasis to the right breast. Nine months later, disorientation and left hemiplegia developed, the right coronal bone metastasis enlarged, and dural metastases were detected close to the tumor, as observed by using cranial magnetic resonance imaging (MRI). Whole brain radiation and chemotherapy (weekly paclitaxel) were administered. The right coronal bone metastasis reduced remarkably/and the dural metastases almost disappeared, as observed on a cranial MRl scan. The second case of dural metastasis occurred in a 50s years old woman who presented with multiple bone metastases. Extensive bone metastases to the skull and dural metastases to the side of the head were observed on cranial MRI scans. Subsequently, the patient experienced a severe headache, and whole brain radiation and pharmacotherapy with anastrozole and trastuzumab were administered. Cranial MRI revealed that the skull bone metastasis reduced and the dural metastases almost disappeared. We report that radiotherapy and pharmacotherapy were effective in these 2 cases of dural metastases of breast cancer.

Original languageEnglish
Pages (from-to)1906-1908
Number of pages3
JournalJapanese Journal of Cancer and Chemotherapy
Issue number12
Publication statusPublished - Nov 2014


  • Breast cancer
  • Dural metastasis

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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