Two Operated Cases of Lung Cancer Showing Humoral Hypercalcemia of Malignancy (HHM)

Masato Minami, Kazuya Nakahara, Shinichiro Miyoshi, Akinori Akashi, Takatoshi Mizuta, Shigeto Morimoto

Research output: Contribution to journalArticlepeer-review


Two cases of lung cancer and hypercalcemia (Case 1: 66-year-old male; adenocarcinoma, Case 2: 63-year-old male; squamous cell carcinoma) were diagnosed as humoral hypercalcemia of malignancy (HHM) based on the results of bone scintigram and the laboratory findings concerning Ca metabolism. In both patients hypercalcemia and disturbed consciousness improved transiently after administration of mithramycin and preoperative evaluation could be accomplished. A right upper sleeve lobectomy was performed in Case 1 (p-T3N0M0) and hypercalcemia temporarily disappeared postoperatively, but he died of metastases on the 73rd postoperative day. Thoracotomy in Case 2 revealed the tumor to be unresectable because of pleural dissemination (p-T4N2M1) and he died of hypercalcemia on the 18th postoperative day. In summary, in two lung cancer patients diagnosed as HHM operation was indicated but their prognoses were extremely poor.

Original languageEnglish
Pages (from-to)591-597
Number of pages7
Issue number4
Publication statusPublished - Jan 1991


  • Humoral factor
  • Humoral hypercalcemia of malignancy (HHM)
  • Hypercalcemia
  • Lung cancer
  • Operation

ASJC Scopus subject areas

  • Oncology
  • Pulmonary and Respiratory Medicine


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