Tyrokeradines G and H, new bromotyrosine alkaloids from an Okinawan Verongid sponge

Takaaki Kubota, Shinya Watase, Kanae Sakai, Jane Fromont, Tohru Gonoi, Jun'Ichi Kobayashi

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


Two new bromotyrosine alkaloids, tyrokeradines G (1) and H (2), have been isolated from an Okinawan marine sponge of the order Verongida. The structures of 1 and 2 were elucidated on the basis of spectroscopic data. Tyrokeradine G (1) is the first bromotyrosine alkaloid possessing a β-alanine unit, while tyrokeradine H (2) is a rare bromotyrosine alkaloid possessing a N-substituted pyridinium ring. Tyrokeradines G (1) and H (2) showed antifungal activity.

Original languageEnglish
Pages (from-to)5221-5223
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Issue number22
Publication statusPublished - Nov 15 2015
Externally publishedYes


  • Antifungal activity
  • Bromotyrosine alkaloid
  • Marine sponge
  • Order Verongida

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry


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