Ulcer Formation in Rat Stomach with Diethyldithiocarbamate

Keiki Ogino; Shinji Oka; Shinjiro Matsuura; Isao Sakaida; Shunji Yoshimura; Kazuya Matsuda; Yoshiyuki Sasaki; Kazunari Yamamoto; Yukinori Okazaki; Tadayoshi Takemoto; Toshikazu Yoshikawa

doi:10.3164/jcbn.3.189

Ulcer Formation in Rat Stomach with Diethyldithiocarbamate

Keiki Ogino, Shinji Oka, Shinjiro Matsuura, Isao Sakaida, Shunji Yoshimura, Kazuya Matsuda, Yoshiyuki Sasaki, Kazunari Yamamoto, Yukinori Okazaki, Tadayoshi Takemoto, Toshikazu Yoshikawa

Graduate School of Medicine Dentistry and Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

It has been suggested that superoxide radicals play an important role in the pathogenesis of gastric mucosal lesions after ischemia. To prove a participation of O2^- in gastric mucosal lesion formation, diethyldithiocarbamate (DDC), an inhibitor of Cu,Zn-super-oxide dismutase (SOD), was injected into rats and its ulcerogenicity was examined. Subcutaneous injection of DDC was employed, because of high mortality after intraperitoneal injection of the drug. At 7 h after the injection of the drug, many ulcers appeared in the stomach, with suppression of SOD activities in the gastric mucosa, suggesting the participation of O2^- in ulcer formation in the stomach.

Original language	English
Pages (from-to)	189-193
Number of pages	5
Journal	journal of clinical biochemistry and nutrition
Volume	3
Issue number	3
DOIs	https://doi.org/10.3164/jcbn.3.189
Publication status	Published - 1987

Keywords

diethyldithiocarbamate
rat stomach
ulcer

ASJC Scopus subject areas

Medicine (miscellaneous)
Nutrition and Dietetics
Clinical Biochemistry

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10.3164/jcbn.3.189

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title = "Ulcer Formation in Rat Stomach with Diethyldithiocarbamate",

abstract = "It has been suggested that superoxide radicals play an important role in the pathogenesis of gastric mucosal lesions after ischemia. To prove a participation of O2- in gastric mucosal lesion formation, diethyldithiocarbamate (DDC), an inhibitor of Cu,Zn-super-oxide dismutase (SOD), was injected into rats and its ulcerogenicity was examined. Subcutaneous injection of DDC was employed, because of high mortality after intraperitoneal injection of the drug. At 7 h after the injection of the drug, many ulcers appeared in the stomach, with suppression of SOD activities in the gastric mucosa, suggesting the participation of O2- in ulcer formation in the stomach.",

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author = "Keiki Ogino and Shinji Oka and Shinjiro Matsuura and Isao Sakaida and Shunji Yoshimura and Kazuya Matsuda and Yoshiyuki Sasaki and Kazunari Yamamoto and Yukinori Okazaki and Tadayoshi Takemoto and Toshikazu Yoshikawa",

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T1 - Ulcer Formation in Rat Stomach with Diethyldithiocarbamate

AU - Ogino, Keiki

AU - Oka, Shinji

AU - Matsuura, Shinjiro

AU - Sakaida, Isao

AU - Yoshimura, Shunji

AU - Matsuda, Kazuya

AU - Sasaki, Yoshiyuki

AU - Yamamoto, Kazunari

AU - Okazaki, Yukinori

AU - Takemoto, Tadayoshi

AU - Yoshikawa, Toshikazu

PY - 1987

Y1 - 1987

N2 - It has been suggested that superoxide radicals play an important role in the pathogenesis of gastric mucosal lesions after ischemia. To prove a participation of O2- in gastric mucosal lesion formation, diethyldithiocarbamate (DDC), an inhibitor of Cu,Zn-super-oxide dismutase (SOD), was injected into rats and its ulcerogenicity was examined. Subcutaneous injection of DDC was employed, because of high mortality after intraperitoneal injection of the drug. At 7 h after the injection of the drug, many ulcers appeared in the stomach, with suppression of SOD activities in the gastric mucosa, suggesting the participation of O2- in ulcer formation in the stomach.

AB - It has been suggested that superoxide radicals play an important role in the pathogenesis of gastric mucosal lesions after ischemia. To prove a participation of O2- in gastric mucosal lesion formation, diethyldithiocarbamate (DDC), an inhibitor of Cu,Zn-super-oxide dismutase (SOD), was injected into rats and its ulcerogenicity was examined. Subcutaneous injection of DDC was employed, because of high mortality after intraperitoneal injection of the drug. At 7 h after the injection of the drug, many ulcers appeared in the stomach, with suppression of SOD activities in the gastric mucosa, suggesting the participation of O2- in ulcer formation in the stomach.

KW - diethyldithiocarbamate

KW - rat stomach

KW - ulcer

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Ulcer Formation in Rat Stomach with Diethyldithiocarbamate

Abstract

Keywords

ASJC Scopus subject areas

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