TY - JOUR
T1 - Unexpected correlation in the sensitivity of 19 herpes simplex virus strains to types I and II interferons
AU - Arao, Y.
AU - Ando, Y.
AU - Narita, M.
AU - Kurata, T.
PY - 1997/9
Y1 - 1997/9
N2 - We compared the sensitivity of 19 herpes simplex virus (HSV) strains to type I (IFN-α and IFN-β) and type II (IFN-γ) human interferons in cultures of human retinal epithelial (K-1034) and lung (HEL) cells. Their sensitivities proved to be well correlated, even though type I and type II IFN have been reported to have different antiviral actions. The correlation was not because IFN-γ stimulated the formation of IFN-β, for an antibody that neutralized IFN-β did not reduce its inhibitory effects. Our results show that each HSV strain has a characteristic and similar sensitivity to type I and type II IFN and suggest some common pathway in the mechanism of their antiviral actions.
AB - We compared the sensitivity of 19 herpes simplex virus (HSV) strains to type I (IFN-α and IFN-β) and type II (IFN-γ) human interferons in cultures of human retinal epithelial (K-1034) and lung (HEL) cells. Their sensitivities proved to be well correlated, even though type I and type II IFN have been reported to have different antiviral actions. The correlation was not because IFN-γ stimulated the formation of IFN-β, for an antibody that neutralized IFN-β did not reduce its inhibitory effects. Our results show that each HSV strain has a characteristic and similar sensitivity to type I and type II IFN and suggest some common pathway in the mechanism of their antiviral actions.
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U2 - 10.1089/jir.1997.17.537
DO - 10.1089/jir.1997.17.537
M3 - Article
C2 - 9335431
AN - SCOPUS:0030661745
SN - 1079-9907
VL - 17
SP - 537
EP - 541
JO - Journal of Interferon and Cytokine Research
JF - Journal of Interferon and Cytokine Research
IS - 9
ER -