TY - JOUR
T1 - Upregulation of insulin-like growth factor receptor gene in experimental diabetic rat glomeruli
AU - Sugimoto, Hikaru
AU - Shikata, Kenichi
AU - Makino, Hirofumi
AU - Ota, Kosuke
AU - Ota, Zensuke
N1 - Funding Information:
This work was supported by a grant-in-aid for Scientific Research (A-04404039, C-0467148) from the Ministry of Education, Science, and Culture.
PY - 1995
Y1 - 1995
N2 - Renal hypertrophy is a characteristic and early manifestation of diabetes in human and experimental animals. We examined the precise distribution of insulin-like growth factor-I (IGF-I) receptor mRNA in the experimental diabetic rat kidney using a nonradioactive in situ hybridization technique. Expression of IGF-I receptor mRNA was rarely seen in the glomeruli of control rats. IGF-I receptor mRNA was detected after induction of diabetes in glomerular mesangial, visceral epithelial, and parietal epithelial cells. The number of IGF-I receptor mRNA-positive cells in a glomerulus increased significantly at 4 weeks as compared with the control rats. Overexpression of IGF-I receptor in glomerular cells may contribute to the glomerular hypertrophy in diabetic nephropathy.
AB - Renal hypertrophy is a characteristic and early manifestation of diabetes in human and experimental animals. We examined the precise distribution of insulin-like growth factor-I (IGF-I) receptor mRNA in the experimental diabetic rat kidney using a nonradioactive in situ hybridization technique. Expression of IGF-I receptor mRNA was rarely seen in the glomeruli of control rats. IGF-I receptor mRNA was detected after induction of diabetes in glomerular mesangial, visceral epithelial, and parietal epithelial cells. The number of IGF-I receptor mRNA-positive cells in a glomerulus increased significantly at 4 weeks as compared with the control rats. Overexpression of IGF-I receptor in glomerular cells may contribute to the glomerular hypertrophy in diabetic nephropathy.
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U2 - 10.1016/1056-8727(95)80017-9
DO - 10.1016/1056-8727(95)80017-9
M3 - Article
C2 - 8573742
AN - SCOPUS:0028803913
SN - 1056-8727
VL - 9
SP - 262
EP - 264
JO - Journal of Diabetes and its Complications
JF - Journal of Diabetes and its Complications
IS - 4
ER -
