Urethral tumor induced by methotrexate-associated lymphoproliferative disorders: A case report

Kasumi Kawamura; Yuki Maruyama; Takuya Sadahira; Yosuke Mitsui; Shingo Nishimura; Atsushi Takamoto; Seiji Kai; Koichiro Wada; Ryuta Tanimoto; Morito Sugimoto; Yasuyuki Kobayashi; Motoo Araki; Masami Watanabe; Toyohiko Watanabe; Yasutomo Nasu; Takehiro Tanaka

Urethral tumor induced by methotrexate-associated lymphoproliferative disorders: A case report

Kasumi Kawamura, Yuki Maruyama, Takuya Sadahira, Yosuke Mitsui, Shingo Nishimura, Atsushi Takamoto, Seiji Kai, Koichiro Wada, Ryuta Tanimoto, Morito Sugimoto, Yasuyuki Kobayashi, Motoo Araki, Masami Watanabe, Toyohiko Watanabe, Yasutomo Nasu, Takehiro Tanaka

Research output: Contribution to journal › Article › peer-review

Abstract

A 64-year-old woman who had recurrent fever was referred to our hospital. She had been diagnosed with rheumatoid arthritis (RA) in 2007 and treated with methotrexate (MTX) therapy since 2008. She had the same symptoms in 2015. At that time, Cervical cancer and lung metastasis were suspected from computed tomography (CT) scan. Cervical punch biopsy revealed no malignancy. The lung nodules and her symptoms disappeared on spontaneous regression. CT scan showed left pyelectasis, left ureteral stenosis, urethral tumor and various parts of lymphadenopathy. ¹⁸F-fluorodeoxyglucose positron emission tomography (FDG-PET/CT) showed an uptake of FDG in the left renal hilar lymph node, the urethra and the nasopharynx. MTX-associated lymphoproliferative disorders (MTX-LPD) were suspected rather than metastatic urothelial carcinoma. Pathological examination of the nasopharynx biopsy showed Hodgkin's lymphoma, and Epstein-Barr-encoding region in situ hybridization (EBER-ISH) stain was positive. MTX-LPD was diagnosed. One year after MTX withdrawal, tumors of the left ureter and the urethra remain, but other lesions have shown regression in size.

Original language	English
Pages (from-to)	678-683
Number of pages	6
Journal	Nishinihon Journal of Urology
Volume	80
Issue number	12
Publication status	Published - Dec 2018

Keywords

Hodgkin's lymphoma
Methotrexate
Methotrexate-associated lymphoproliferative disorders
Rheumatoid arthritis
Urethra

ASJC Scopus subject areas

Urology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "Urethral tumor induced by methotrexate-associated lymphoproliferative disorders: A case report",

abstract = "A 64-year-old woman who had recurrent fever was referred to our hospital. She had been diagnosed with rheumatoid arthritis (RA) in 2007 and treated with methotrexate (MTX) therapy since 2008. She had the same symptoms in 2015. At that time, Cervical cancer and lung metastasis were suspected from computed tomography (CT) scan. Cervical punch biopsy revealed no malignancy. The lung nodules and her symptoms disappeared on spontaneous regression. CT scan showed left pyelectasis, left ureteral stenosis, urethral tumor and various parts of lymphadenopathy. 18F-fluorodeoxyglucose positron emission tomography (FDG-PET/CT) showed an uptake of FDG in the left renal hilar lymph node, the urethra and the nasopharynx. MTX-associated lymphoproliferative disorders (MTX-LPD) were suspected rather than metastatic urothelial carcinoma. Pathological examination of the nasopharynx biopsy showed Hodgkin's lymphoma, and Epstein-Barr-encoding region in situ hybridization (EBER-ISH) stain was positive. MTX-LPD was diagnosed. One year after MTX withdrawal, tumors of the left ureter and the urethra remain, but other lesions have shown regression in size.",

keywords = "Hodgkin's lymphoma, Methotrexate, Methotrexate-associated lymphoproliferative disorders, Rheumatoid arthritis, Urethra",

author = "Kasumi Kawamura and Yuki Maruyama and Takuya Sadahira and Yosuke Mitsui and Shingo Nishimura and Atsushi Takamoto and Seiji Kai and Koichiro Wada and Ryuta Tanimoto and Morito Sugimoto and Yasuyuki Kobayashi and Motoo Araki and Masami Watanabe and Toyohiko Watanabe and Yasutomo Nasu and Takehiro Tanaka",

year = "2018",

month = dec,

language = "English",

volume = "80",

pages = "678--683",

journal = "Nishinihon Journal of Urology",

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publisher = "Kyushu University, Faculty of Science",

number = "12",

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TY - JOUR

T1 - Urethral tumor induced by methotrexate-associated lymphoproliferative disorders

T2 - A case report

AU - Kawamura, Kasumi

AU - Maruyama, Yuki

AU - Sadahira, Takuya

AU - Mitsui, Yosuke

AU - Nishimura, Shingo

AU - Takamoto, Atsushi

AU - Kai, Seiji

AU - Wada, Koichiro

AU - Tanimoto, Ryuta

AU - Sugimoto, Morito

AU - Kobayashi, Yasuyuki

AU - Araki, Motoo

AU - Watanabe, Masami

AU - Watanabe, Toyohiko

AU - Nasu, Yasutomo

AU - Tanaka, Takehiro

PY - 2018/12

Y1 - 2018/12

N2 - A 64-year-old woman who had recurrent fever was referred to our hospital. She had been diagnosed with rheumatoid arthritis (RA) in 2007 and treated with methotrexate (MTX) therapy since 2008. She had the same symptoms in 2015. At that time, Cervical cancer and lung metastasis were suspected from computed tomography (CT) scan. Cervical punch biopsy revealed no malignancy. The lung nodules and her symptoms disappeared on spontaneous regression. CT scan showed left pyelectasis, left ureteral stenosis, urethral tumor and various parts of lymphadenopathy. 18F-fluorodeoxyglucose positron emission tomography (FDG-PET/CT) showed an uptake of FDG in the left renal hilar lymph node, the urethra and the nasopharynx. MTX-associated lymphoproliferative disorders (MTX-LPD) were suspected rather than metastatic urothelial carcinoma. Pathological examination of the nasopharynx biopsy showed Hodgkin's lymphoma, and Epstein-Barr-encoding region in situ hybridization (EBER-ISH) stain was positive. MTX-LPD was diagnosed. One year after MTX withdrawal, tumors of the left ureter and the urethra remain, but other lesions have shown regression in size.

AB - A 64-year-old woman who had recurrent fever was referred to our hospital. She had been diagnosed with rheumatoid arthritis (RA) in 2007 and treated with methotrexate (MTX) therapy since 2008. She had the same symptoms in 2015. At that time, Cervical cancer and lung metastasis were suspected from computed tomography (CT) scan. Cervical punch biopsy revealed no malignancy. The lung nodules and her symptoms disappeared on spontaneous regression. CT scan showed left pyelectasis, left ureteral stenosis, urethral tumor and various parts of lymphadenopathy. 18F-fluorodeoxyglucose positron emission tomography (FDG-PET/CT) showed an uptake of FDG in the left renal hilar lymph node, the urethra and the nasopharynx. MTX-associated lymphoproliferative disorders (MTX-LPD) were suspected rather than metastatic urothelial carcinoma. Pathological examination of the nasopharynx biopsy showed Hodgkin's lymphoma, and Epstein-Barr-encoding region in situ hybridization (EBER-ISH) stain was positive. MTX-LPD was diagnosed. One year after MTX withdrawal, tumors of the left ureter and the urethra remain, but other lesions have shown regression in size.

KW - Hodgkin's lymphoma

KW - Methotrexate

KW - Methotrexate-associated lymphoproliferative disorders

KW - Rheumatoid arthritis

KW - Urethra

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SN - 0029-0726

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JO - Nishinihon Journal of Urology

JF - Nishinihon Journal of Urology

IS - 12

ER -

Urethral tumor induced by methotrexate-associated lymphoproliferative disorders: A case report

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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