Uricase-like catalytic activity of ion-exchange resins modified with metalloporphyrins

Masaki Mifune; Junichi Odo; Akimasa Iwado; Yutaka Saito; Noriko Motohashi; Masahiko Chikuma; Hisahasi Tanaka

doi:10.1016/0039-9140(91)80200-J

Uricase-like catalytic activity of ion-exchange resins modified with metalloporphyrins

Masaki Mifune, Junichi Odo, Akimasa Iwado, Yutaka Saito, Noriko Motohashi, Masahiko Chikuma, Hisahasi Tanaka

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

The uricase-like catalytic activity of the ion-exchange resins modified with metalloporphyrins has been investigated through the oxidation of uric acid. The anion-exchange resins modified with Mn³⁺-tetrakis(sulfophenyl)porphine and the cation-exchange resin modified with Mn³⁺-tetrakis(1-methylpyridinium-4-yl)porphine exhibited the highest uricase-like activity among the modified resins tested. The fact that these resins accelerated the oxidation of uric acid even after ten cycles of use indicates that the modified resins act as catalysts in the reaction catalysed by uricase. Some of the modified resins may be effectively used for the determination of uric acid in place of uricase.

Original language	English
Pages (from-to)	779-783
Number of pages	5
Journal	Talanta
Volume	38
Issue number	7
DOIs	https://doi.org/10.1016/0039-9140(91)80200-J
Publication status	Published - Jul 1991

ASJC Scopus subject areas

Analytical Chemistry

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10.1016/0039-9140(91)80200-J

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@article{829b749eb2ef4a3ea18f39c8e26a54f8,

title = "Uricase-like catalytic activity of ion-exchange resins modified with metalloporphyrins",

abstract = "The uricase-like catalytic activity of the ion-exchange resins modified with metalloporphyrins has been investigated through the oxidation of uric acid. The anion-exchange resins modified with Mn3+-tetrakis(sulfophenyl)porphine and the cation-exchange resin modified with Mn3+-tetrakis(1-methylpyridinium-4-yl)porphine exhibited the highest uricase-like activity among the modified resins tested. The fact that these resins accelerated the oxidation of uric acid even after ten cycles of use indicates that the modified resins act as catalysts in the reaction catalysed by uricase. Some of the modified resins may be effectively used for the determination of uric acid in place of uricase.",

author = "Masaki Mifune and Junichi Odo and Akimasa Iwado and Yutaka Saito and Noriko Motohashi and Masahiko Chikuma and Hisahasi Tanaka",

note = "Funding Information: Acknowledgements-The authors thank Miss Atsuko Taguchi for her technical assistance.T his work was supported in part by a Grant-in-Aid for Scientific Researchf rom the Ministry of Education, Sciencea nd Culture,J apan.",

year = "1991",

month = jul,

doi = "10.1016/0039-9140(91)80200-J",

language = "English",

volume = "38",

pages = "779--783",

journal = "Talanta",

issn = "0039-9140",

publisher = "Elsevier",

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T1 - Uricase-like catalytic activity of ion-exchange resins modified with metalloporphyrins

AU - Mifune, Masaki

AU - Odo, Junichi

AU - Iwado, Akimasa

AU - Saito, Yutaka

AU - Motohashi, Noriko

AU - Chikuma, Masahiko

AU - Tanaka, Hisahasi

N1 - Funding Information: Acknowledgements-The authors thank Miss Atsuko Taguchi for her technical assistance.T his work was supported in part by a Grant-in-Aid for Scientific Researchf rom the Ministry of Education, Sciencea nd Culture,J apan.

PY - 1991/7

Y1 - 1991/7

N2 - The uricase-like catalytic activity of the ion-exchange resins modified with metalloporphyrins has been investigated through the oxidation of uric acid. The anion-exchange resins modified with Mn3+-tetrakis(sulfophenyl)porphine and the cation-exchange resin modified with Mn3+-tetrakis(1-methylpyridinium-4-yl)porphine exhibited the highest uricase-like activity among the modified resins tested. The fact that these resins accelerated the oxidation of uric acid even after ten cycles of use indicates that the modified resins act as catalysts in the reaction catalysed by uricase. Some of the modified resins may be effectively used for the determination of uric acid in place of uricase.

AB - The uricase-like catalytic activity of the ion-exchange resins modified with metalloporphyrins has been investigated through the oxidation of uric acid. The anion-exchange resins modified with Mn3+-tetrakis(sulfophenyl)porphine and the cation-exchange resin modified with Mn3+-tetrakis(1-methylpyridinium-4-yl)porphine exhibited the highest uricase-like activity among the modified resins tested. The fact that these resins accelerated the oxidation of uric acid even after ten cycles of use indicates that the modified resins act as catalysts in the reaction catalysed by uricase. Some of the modified resins may be effectively used for the determination of uric acid in place of uricase.

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U2 - 10.1016/0039-9140(91)80200-J

DO - 10.1016/0039-9140(91)80200-J

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VL - 38

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EP - 783

JO - Talanta

JF - Talanta

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ER -

Uricase-like catalytic activity of ion-exchange resins modified with metalloporphyrins

Abstract

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