Uricase-like catalytic activity of ion-exchange resins modified with metalloporphyrins

Masaki Mifune, Junichi Odo, Akimasa Iwado, Yutaka Saito, Noriko Motohashi, Masahiko Chikuma, Hisahasi Tanaka

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


The uricase-like catalytic activity of the ion-exchange resins modified with metalloporphyrins has been investigated through the oxidation of uric acid. The anion-exchange resins modified with Mn3+-tetrakis(sulfophenyl)porphine and the cation-exchange resin modified with Mn3+-tetrakis(1-methylpyridinium-4-yl)porphine exhibited the highest uricase-like activity among the modified resins tested. The fact that these resins accelerated the oxidation of uric acid even after ten cycles of use indicates that the modified resins act as catalysts in the reaction catalysed by uricase. Some of the modified resins may be effectively used for the determination of uric acid in place of uricase.

Original languageEnglish
Pages (from-to)779-783
Number of pages5
Issue number7
Publication statusPublished - Jul 1991

ASJC Scopus subject areas

  • Analytical Chemistry


Dive into the research topics of 'Uricase-like catalytic activity of ion-exchange resins modified with metalloporphyrins'. Together they form a unique fingerprint.

Cite this