TY - JOUR
T1 - Urinary cross-linked N-terminal telopeptide of type I collagen levels of infants with osteogenesis imperfecta and healthy infants
AU - Yamashita, Miho
AU - Hasegawa, Kosei
AU - Higuchi, Yousuke
AU - Miyai, Takayuki
AU - Okada, Ayumi
AU - Tanaka, Hiroyuki
AU - Tsukahara, Hirokazu
N1 - Funding Information:
This study was supported by a grant from theMinistry of Education, Culture, Sports, Science and Technology, Japan (23791177), and by the Foundation for Growth Science, Japan
Funding Information:
Acknowledgments. This study was supported by a grant from the Ministry of ?ducation, ?ulture, Sports, Science and Technology, ?apan (23791177), and by the ?oundation for ?rowth Science, ?apan.
Publisher Copyright:
© 2017 by Okayama University Medical School.
PY - 2016
Y1 - 2016
N2 - The urinary cross-linked N-terminal telopeptide of type I collagen (uNTx) levels in infantile osteogenesis imperfecta (OI) have not been well studied. Here we investigated the levels of uNTx in infants with OI and healthy infants. We collected spot urine samples from 30 infants with OI (male/female, 14/16; Sillence classification, I/II/III/IV: 15/3/6/6; age, 5.2±4.4 months) and 120 healthy infants (male/female, 75/45; age, 5.1±4.1 months) for the measurement of uNTx levels. The uNTx levels of the OI infants were significantly lower than those of the healthy infants (mean±SD, 1,363.7±530.1 vs. 2,622.2±1,202.6 nmol BCE/mmol Cr; p < 0.001). The uNTx levels of the infants with type I OI were significantly lower than those of the age-matched healthy infants, although an overlap was observed between the 2 groups. Among the 1-month-old infants, the uNTx levels of the infants with types I, III or IV OI were significantly lower than those of the healthy infants, without overlap (1,622.5±235.8 vs. 3,781.0±1,027.1 nmol BCE/mmol Cr; p < 0.001). These results indicate that uNTx levels are significantly lower in infants with OI than in healthy infants, and they suggest that uNTx might be useful as a reference for diagnosing OI.
AB - The urinary cross-linked N-terminal telopeptide of type I collagen (uNTx) levels in infantile osteogenesis imperfecta (OI) have not been well studied. Here we investigated the levels of uNTx in infants with OI and healthy infants. We collected spot urine samples from 30 infants with OI (male/female, 14/16; Sillence classification, I/II/III/IV: 15/3/6/6; age, 5.2±4.4 months) and 120 healthy infants (male/female, 75/45; age, 5.1±4.1 months) for the measurement of uNTx levels. The uNTx levels of the OI infants were significantly lower than those of the healthy infants (mean±SD, 1,363.7±530.1 vs. 2,622.2±1,202.6 nmol BCE/mmol Cr; p < 0.001). The uNTx levels of the infants with type I OI were significantly lower than those of the age-matched healthy infants, although an overlap was observed between the 2 groups. Among the 1-month-old infants, the uNTx levels of the infants with types I, III or IV OI were significantly lower than those of the healthy infants, without overlap (1,622.5±235.8 vs. 3,781.0±1,027.1 nmol BCE/mmol Cr; p < 0.001). These results indicate that uNTx levels are significantly lower in infants with OI than in healthy infants, and they suggest that uNTx might be useful as a reference for diagnosing OI.
KW - Bone mass
KW - Bone resorption marker
KW - Bone turnover
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M3 - Article
C2 - 28003667
AN - SCOPUS:85013069702
SN - 0386-300X
VL - 70
SP - 435
EP - 439
JO - Acta medica Okayama
JF - Acta medica Okayama
IS - 6
ER -