Urinary excretion of aquaporin-2 in term and preterm infants

Hirokazu Tsukahara, Ikue Hata, Kyoichi Sekine, Masakazu Miura, Keishi Hata, Yasushi Fujii, Mitsufumi Mayumi

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


Aquaporin-2 (AQP-2) is a vasopressin-regulated water channel of the renal collecting duct and is excreted in human urine. We measured the urinary excretion of AQP-2 by radioimmunoassay in 14 term and 12 preterm infants aged 1 month. Excretion of AQP-2 was low compared with adults, and correlated significantly with urine osmolality in preterm infants. Our results demonstrate that AQP-2 water channels are expressed in the renal collecting duct of both term and preterm infants.

Original languageEnglish
Pages (from-to)31-37
Number of pages7
JournalEarly Human Development
Issue number1
Publication statusPublished - Apr 17 1998
Externally publishedYes


  • Aquaporin-2
  • Infants
  • Urine
  • Vasopressin
  • Water balance

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynaecology


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