Urinary growth hormone excretion in preterm neonates

Hirokazu Tsukahara; Yasushi Fujii; Masanori Kuriyama; Shinya Tsuchida; Masahiro Hiraoka; Kiyoshi Kikuch; Masakatsu Sudo

doi:10.1159/000243902

Urinary growth hormone excretion in preterm neonates

Hirokazu Tsukahara, Yasushi Fujii, Masanori Kuriyama, Shinya Tsuchida, Masahiro Hiraoka, Kiyoshi Kikuch, Masakatsu Sudo

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

We measured urinary growth hormone (U-GH), β₂micro-globulin (U-B2) and serum growth hormone (S-GH) in preterm neonates on days 1. 4, 7, 14 and 28 of age. U-GH as well as U-B2 were high, particularly in the more premature and sick neonates with respiratory failure requiring mechanical ventilation. U-GH showed significant positive correlations with U-B2 throughout the study but with S-GH only on day 7. Therefore, we conclude that in preterm neonates, U-GH mainly reflects the degree of renal proximal tubular function, which is determined by the degree of renal maturation of the subject and of tubular injury due to disease states such as respiratory failure.

Original language	English
Pages (from-to)	8-13
Number of pages	6
Journal	Neonatology
Volume	63
Issue number	1
DOIs	https://doi.org/10.1159/000243902
Publication status	Published - 1993
Externally published	Yes

Keywords

Preterm neonate
Renal proximal tubular function
Respiratory distress syndrome
Respiratory failure
Ultrasensitive sandwich enzyme immunoassay
Urinary growth hormone
Urinary β<inf>2</inf>-microglobulin

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Developmental Biology

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10.1159/000243902

Cite this

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abstract = "We measured urinary growth hormone (U-GH), β2micro-globulin (U-B2) and serum growth hormone (S-GH) in preterm neonates on days 1. 4, 7, 14 and 28 of age. U-GH as well as U-B2 were high, particularly in the more premature and sick neonates with respiratory failure requiring mechanical ventilation. U-GH showed significant positive correlations with U-B2 throughout the study but with S-GH only on day 7. Therefore, we conclude that in preterm neonates, U-GH mainly reflects the degree of renal proximal tubular function, which is determined by the degree of renal maturation of the subject and of tubular injury due to disease states such as respiratory failure.",

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AU - Tsukahara, Hirokazu

AU - Fujii, Yasushi

AU - Kuriyama, Masanori

AU - Tsuchida, Shinya

AU - Hiraoka, Masahiro

AU - Kikuch, Kiyoshi

AU - Sudo, Masakatsu

PY - 1993

Y1 - 1993

N2 - We measured urinary growth hormone (U-GH), β2micro-globulin (U-B2) and serum growth hormone (S-GH) in preterm neonates on days 1. 4, 7, 14 and 28 of age. U-GH as well as U-B2 were high, particularly in the more premature and sick neonates with respiratory failure requiring mechanical ventilation. U-GH showed significant positive correlations with U-B2 throughout the study but with S-GH only on day 7. Therefore, we conclude that in preterm neonates, U-GH mainly reflects the degree of renal proximal tubular function, which is determined by the degree of renal maturation of the subject and of tubular injury due to disease states such as respiratory failure.

AB - We measured urinary growth hormone (U-GH), β2micro-globulin (U-B2) and serum growth hormone (S-GH) in preterm neonates on days 1. 4, 7, 14 and 28 of age. U-GH as well as U-B2 were high, particularly in the more premature and sick neonates with respiratory failure requiring mechanical ventilation. U-GH showed significant positive correlations with U-B2 throughout the study but with S-GH only on day 7. Therefore, we conclude that in preterm neonates, U-GH mainly reflects the degree of renal proximal tubular function, which is determined by the degree of renal maturation of the subject and of tubular injury due to disease states such as respiratory failure.

KW - Preterm neonate

KW - Renal proximal tubular function

KW - Respiratory distress syndrome

KW - Respiratory failure

KW - Ultrasensitive sandwich enzyme immunoassay

KW - Urinary growth hormone

KW - Urinary β<inf>2</inf>-microglobulin

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Urinary growth hormone excretion in preterm neonates

Abstract

Keywords

ASJC Scopus subject areas

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