Uroguanylin level in umbilical cord blood

H. Tsukahara, K. Sekine, M. Uchiyama, M. Miura, M. Nakazato, Y. Date, W. Tsunezawa, F. Kotsuji, K. Nishida, M. Hiraoka, M. Mayumi

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Background: Uroguanylin is a novel natriuretic and diuretic peptide originally isolated from urine. Methods: To determine whether uroguanylin has a physiologic role during the perinatal period, uroguanylin levels in umbilical cord plasma obtained at the time of delivery were measured by radioimmunoassay and compared with cord serum osmolality. Results: Mean (±SD) cord plasma uroguanylin concentrations (8.8 ± 2.1 fmol/mL) were higher compared with normal adult values. The extent of maturity, mode of delivery and gender did not appear to influence cord uroguanylin levels. The uroguanylin concentration had a significant positive correlation with cord serum osmolality. Conclusion: These findings support some regulatory role of this peptide in perinatal renal and cardiovascular adaptation.

Original languageEnglish
Pages (from-to)267-269
Number of pages3
JournalPediatrics International
Issue number3
Publication statusPublished - 2001
Externally publishedYes


  • Natriuretic peptide
  • Newborn
  • Transition
  • Umbilical cord blood
  • Uroguanylin

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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