Use of ATP Bioluminescence Assay to Evaluate Oral Streptococci

Akari Watanabe, Naofumi Tamaki, Kenji Yokota, Susumu Kokeguchi, Hiro O. Ito, Miwa Matsuyama

Research output: Contribution to journalArticlepeer-review


The statistical correlation between the number of oral streptococci and the results of ATP bioluminescence assay was examined and compared with the results from Streptococcus plate counts and an oral bacteria quantification system. Because a significant correlation was found between ATP(RLU)and the number of bacteria in the oral bacteria quantification system for all seven types of oral streptococci examined, ATP would reflect a conditions of oral hygiene. However, using this assay, it was observed it may be difficult to correctly evaluate bacteria that form aggregates. Furthermore, even a small number of bacteria(below 105 CFU/mL), which cannot be measured by the oral bacteria quantification system, could be estimated by using ATP bioluminescence assay. It was suggested that this assay could be used for quantitative evaluation of the effect of oral cleaning.

Original languageEnglish
Pages (from-to)229-233
Number of pages5
JournalBiocontrol science
Issue number4
Publication statusPublished - 2022


  • ATP bioluminescence assay
  • Oral bacteria quantification system
  • Oral hygiene management
  • Streptococcus plate counts

ASJC Scopus subject areas

  • Medicine(all)


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