TY - JOUR
T1 - Vacuolar Proton Pumps in Malaria Parasite Cells
AU - Moriyama, Yoshinori
AU - Hayashi, Mitsuko
AU - Yatsushiro, Shouki
AU - Yamamoto, Akitsugu
N1 - Funding Information:
The work presented here was supported in part by a Grant-in-Aid for Scientific Research on Priority Areas, 08281105, from the Japanese Ministry of Education, Science, Culture, and Sports. S.Y. and M.H. were supported by Research Fellowships from the Japan Society for the Promotion of Science for Young Scientists.
PY - 2003/8
Y1 - 2003/8
N2 - The malaria parasite is a unicellular protozoan parasite of the genus Plasmodium that causes one of the most serious infectious diseases for human beings. Like other protozoa, the malaria parasite possesses acidic organelles, which may play an essential role(s) in energy acquisition, resistance to antimalarial agents, and vesicular trafficking. Recent evidence has indicated that two types of vacuolar proton pumps, vacuolar H+-ATPase and vacuolar H+-pyrophosphatase, are responsible for their acidification. In this mini-review, we discuss the recent progress on vacuolar proton pumps in the malaria parasite.
AB - The malaria parasite is a unicellular protozoan parasite of the genus Plasmodium that causes one of the most serious infectious diseases for human beings. Like other protozoa, the malaria parasite possesses acidic organelles, which may play an essential role(s) in energy acquisition, resistance to antimalarial agents, and vesicular trafficking. Recent evidence has indicated that two types of vacuolar proton pumps, vacuolar H+-ATPase and vacuolar H+-pyrophosphatase, are responsible for their acidification. In this mini-review, we discuss the recent progress on vacuolar proton pumps in the malaria parasite.
KW - Malaria parasite
KW - Plasmodium falciparum
KW - Vacuolar H-ATPase
KW - Vacuolar H-pyrophosphatase
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U2 - 10.1023/A:1025785000544
DO - 10.1023/A:1025785000544
M3 - Short survey
C2 - 14635782
AN - SCOPUS:0142025300
SN - 0145-479X
VL - 35
SP - 367
EP - 375
JO - Journal of Bioenergetics and Biomembranes
JF - Journal of Bioenergetics and Biomembranes
IS - 4
ER -
