Vacuolar Proton Pumps in Malaria Parasite Cells

Yoshinori Moriyama, Mitsuko Hayashi, Shouki Yatsushiro, Akitsugu Yamamoto

Research output: Contribution to journalShort surveypeer-review

14 Citations (Scopus)


The malaria parasite is a unicellular protozoan parasite of the genus Plasmodium that causes one of the most serious infectious diseases for human beings. Like other protozoa, the malaria parasite possesses acidic organelles, which may play an essential role(s) in energy acquisition, resistance to antimalarial agents, and vesicular trafficking. Recent evidence has indicated that two types of vacuolar proton pumps, vacuolar H+-ATPase and vacuolar H+-pyrophosphatase, are responsible for their acidification. In this mini-review, we discuss the recent progress on vacuolar proton pumps in the malaria parasite.

Original languageEnglish
Pages (from-to)367-375
Number of pages9
JournalJournal of Bioenergetics and Biomembranes
Issue number4
Publication statusPublished - Aug 2003


  • Malaria parasite
  • Plasmodium falciparum
  • Vacuolar H-ATPase
  • Vacuolar H-pyrophosphatase

ASJC Scopus subject areas

  • Physiology
  • Cell Biology


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