TY - JOUR
T1 - Variations in the FTO gene are associated with severe obesity in the Japanese
AU - Hotta, Kikuko
AU - Nakata, Yoshio
AU - Matsuo, Tomoaki
AU - Kamohara, Seika
AU - Kotani, Kazuaki
AU - Komatsu, Ryoya
AU - Itoh, Naoto
AU - Mineo, Ikuo
AU - Wada, Jun
AU - Masuzaki, Hiroaki
AU - Yoneda, Masato
AU - Nakajima, Atsushi
AU - Miyazaki, Shigeru
AU - Tokunaga, Katsuto
AU - Kawamoto, Manabu
AU - Funahashi, Tohru
AU - Hamaguchi, Kazuyuki
AU - Yamada, Kentaro
AU - Hanafusa, Toshiaki
AU - Oikawa, Shinichi
AU - Yoshimatsu, Hironobu
AU - Nakao, Kazuwa
AU - Sakata, Toshiie
AU - Matsuzawa, Yuji
AU - Tanaka, Kiyoji
AU - Kamatani, Naoyuki
AU - Nakamura, Yusuke
PY - 2008/6
Y1 - 2008/6
N2 - Variations in the fat-mass and obesity-associated gene (FTO) are associated with the obesity phenotype in many Caucasian populations. This association with the obesity phenotype is not clear in the Japanese. To investigate the relationship between the FTO gene and obesity in the Japanese, we genotyped single nucleotide polymorphisms (SNPs) in the FTO genes from severely obese subjects [n = 927, body mass index (BMI) ≥ 30 kg/m2] and normal-weight control subjects (n = 1,527, BMI < 25 kg/m2). A case-control association analysis revealed that 15 SNPs, including rs9939609 and rs1121980, in a linkage disequilibrium (LD) block of approximately 50 kb demonstrated significant associations with obesity; rs1558902 was most significantly associated with obesity. P value in additive mode was 0.0000041, and odds ratio (OR) adjusted for age and gender was 1.41 [95% confidential interval (CI) = 1.22-1.62]. Obesity-associated phenotypes, which include the level of plasma glucose, hemoglobin A1c, total cholesterol, triglycerides, high-density lipoprotein (HDL) cholesterol, and blood pressure were not associated with the rs1558902 genotype. Thus, the SNPs in the FTO gene were found to be associated with obesity, i.e., severe obesity, in the Japanese.
AB - Variations in the fat-mass and obesity-associated gene (FTO) are associated with the obesity phenotype in many Caucasian populations. This association with the obesity phenotype is not clear in the Japanese. To investigate the relationship between the FTO gene and obesity in the Japanese, we genotyped single nucleotide polymorphisms (SNPs) in the FTO genes from severely obese subjects [n = 927, body mass index (BMI) ≥ 30 kg/m2] and normal-weight control subjects (n = 1,527, BMI < 25 kg/m2). A case-control association analysis revealed that 15 SNPs, including rs9939609 and rs1121980, in a linkage disequilibrium (LD) block of approximately 50 kb demonstrated significant associations with obesity; rs1558902 was most significantly associated with obesity. P value in additive mode was 0.0000041, and odds ratio (OR) adjusted for age and gender was 1.41 [95% confidential interval (CI) = 1.22-1.62]. Obesity-associated phenotypes, which include the level of plasma glucose, hemoglobin A1c, total cholesterol, triglycerides, high-density lipoprotein (HDL) cholesterol, and blood pressure were not associated with the rs1558902 genotype. Thus, the SNPs in the FTO gene were found to be associated with obesity, i.e., severe obesity, in the Japanese.
KW - Association
KW - Fat-mass and obesity-associated gene
KW - Japanese population
KW - Obesity
KW - SNP
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U2 - 10.1007/s10038-008-0283-1
DO - 10.1007/s10038-008-0283-1
M3 - Article
C2 - 18379722
AN - SCOPUS:44349129013
SN - 1434-5161
VL - 53
SP - 546
EP - 553
JO - Jinrui idengaku zasshi. The Japanese journal of human genetics
JF - Jinrui idengaku zasshi. The Japanese journal of human genetics
IS - 6
ER -
