Verbal or Visual Memory Score and Regional Cerebral Blood Flow in Alzheimer Disease

Satoshi Hayashi, Seishi Terada, Etsuko Oshima, Shuhei Sato, Kairi Kurisu, Shintaro Takenoshita, Osamu Yokota, Norihito Yamada

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


Objective: Among many cognitive function deficits, memory impairment is an initial and cardinal symptom in Alzheimer disease (AD). In most cases, verbal and visual memory scores correlate highly, but in some cases the deficit of verbal or visual memory is very different from that of the other memory. In this study, we examined the neural substrates of verbal and visual memory in patients with AD. Methods: One hundred eighty-eight consecutive patients with AD were recruited from outpatient units. Verbal and visual memory scores were evaluated using the Wechsler Memory Scale-revised. The patients underwent brain SPECT with 99mTc-ethylcysteinate dimer. Results: After removing the effects of age, sex, education, and Mini-Mental State Examination scores, correlation analysis showed a significant correlation of verbal memory scores to regional cerebral blood flow (rCBF) in the bilateral cingulate gyrus and left precuneus. Similarly, a significant correlation of visual memory scores to rCBF was found in the right precuneus and right cingulate gyrus. Conclusion: The posterior medial cortices (PMC) are very important areas in episodic memory among patients with mild AD. Verbal memory is more closely related to the both sides of the PMC, while visual memory is more closely related to the right PMC.

Original languageEnglish
Pages (from-to)1-11
Number of pages11
JournalDementia and Geriatric Cognitive Disorders Extra
Issue number1
Publication statusPublished - Jan 1 2018


  • Alzheimer disease
  • Cerebral blood flow
  • Memory
  • Verbal memory
  • Visual memory

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Psychiatry and Mental health


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