Vibrio vulnificus induces macrophage apoptosis in vitro and in vivo

Takashige Kashimoto, Shunji Ueno, Miyuki Hanajima, Hisae Hayashi, Yukihiro Akeda, Shinichi Miyoshi, Toshiharu Hongo, Takeshi Honda, Nobuyuki Susa

Research output: Contribution to journalArticlepeer-review

40 Citations (Scopus)


In this study, we compared the apoptotic activities of clinical and environmental isolates of Vibrio vulnificus toward macrophages in vitro and in vivo. The clinical isolates induced apoptosis in macrophage-like cells in vitro and in macrophages in vivo. This suggests that macrophage apoptosis may be important for the clinical virulence of V. vulnificus.

Original languageEnglish
Pages (from-to)533-535
Number of pages3
JournalInfection and Immunity
Issue number1
Publication statusPublished - Jan 1 2003

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases


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