@article{71e6d4cf85f04647a86e819e76c7db1d,
title = "Wash-free detection of C-reactive protein based on third-harmonic signal measurement of magnetic markers",
abstract = "We demonstrate wash-free detection of C-reactive proteins (CRPs) based on third-harmonic signal measurement of magnetic markers. In the method presented here, the CRP concentration can be detected from the decrease in the third-harmonic signal from the sample solution. The relationship between the detected signal and the CRP concentration can be modeled quantitatively using a logistic function. The quantities of CRP that were detected using the proposed method showed good correlation with those obtained using the conventional optical method with a washing process. We also demonstrate CRP detection in a hemolysis sample solution that is not optically transparent.",
author = "Keiji Enpuku and Misako Shibakura and Yujiro Arao and Takako Mizoguchi and Akihiko Kandori and Misato Hara and Keiji Tsukada",
note = "Funding Information: This work was partly supported by the Strategic Promotion of Innovative Research and Development Program of the Japan Science and Technology Agency (Grant No. 200904001), and by a Grant-in-Aid for Scientific Research (S) (Grant No. JP15H05764) from the Japan Society for the Promotion of Science. The authors would like to thank K. Tsunashima, K. Jinno, K. Fujimoto, S. Takeuchi, and K. Fukuda for their assistance with the experiments. Funding Information: Acknowledgements This work was partly supported by the Strategic Promotion of Innovative Research and Development Program of the Japan Science and Technology Agency (Grant No. 200904001), and by a Grant-in-Aid for Scientific Research (S) (Grant No. JP15H05764) from the Japan Society for the Promotion of Science. The authors would like to thank K. Tsunashima, K. Jinno, K. Fujimoto, S. Takeuchi, and K. Fukuda for their assistance with the experiments. Publisher Copyright: {\textcopyright} 2018 The Japan Society of Applied Physics.",
year = "2018",
month = sep,
doi = "10.7567/JJAP.57.090309",
language = "English",
volume = "57",
journal = "Japanese Journal of Applied Physics",
issn = "0021-4922",
publisher = "INSTITUTE OF PURE AND APPLIED PHYSICS",
number = "9",
}