Abstract
Water sorption and glass transition of four amorphous sugars (lactose, maltose, sucrose, and trehalose) containing bovine serum albumin (BSA) are investigated. Freeze-dried sugar-BSA samples equilibrated at several water activities ranging from 0 to 0.43 were prepared. Moisture content and glass transition temperature (T(g)) were measured. For the all sugars, it is found that BSA lowers T(g) at low water activity, and raises it at high water activity. It is also found that the difference between T(g) of the sugar-BSA samples and that of the corresponding amorphous sugar samples (T(g0)) depends mainly on T(g0).
| Original language | English |
|---|---|
| Pages (from-to) | 657-660 |
| Number of pages | 4 |
| Journal | JOURNAL OF CHEMICAL ENGINEERING OF JAPAN |
| Volume | 33 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Jan 1 2000 |
| Externally published | Yes |
Keywords
- Amorphous sugar
- BSA
- Freeze-drying
- Glass transition temperature
- Water sorption
ASJC Scopus subject areas
- Chemistry(all)
- Chemical Engineering(all)