TY - JOUR
T1 - Wegener granulomatosis manifesting as meningitis
T2 - Case report
AU - Yasuhara, Takao
AU - Fukuhara, Toru
AU - Nakagawa, Minoru
AU - Terai, Yoshinori
AU - Yoshino, Kimihiro
AU - Mizobuchi, Koichi
AU - Fujimoto, Shunichiro
PY - 2002/11/1
Y1 - 2002/11/1
N2 - The authors describe a unique presentation of Wegener granulomatosis (WG) manifesting predominantly as meningitis. Magnetic resonance imaging demonstrated diffuse meningeal enhancement, including the pia mater, in a 28-year-old man with meningitis. A diagnosis of atypical WG was based on the findings of a dural biopsy sample and an elevated cytoplasmic antineutrophil cytoplasmic antibody (cANCA) titer, although the patient did not have any of the lesions common to WG. Immunosuppressive therapy was quite effective. With treatment, the meningeal enhancement resolved and the cANCA titer normalized. Meningeal granulomatosis as the sole lesion in WG has never been reported in the literature. This atypical course of WG should be noted.
AB - The authors describe a unique presentation of Wegener granulomatosis (WG) manifesting predominantly as meningitis. Magnetic resonance imaging demonstrated diffuse meningeal enhancement, including the pia mater, in a 28-year-old man with meningitis. A diagnosis of atypical WG was based on the findings of a dural biopsy sample and an elevated cytoplasmic antineutrophil cytoplasmic antibody (cANCA) titer, although the patient did not have any of the lesions common to WG. Immunosuppressive therapy was quite effective. With treatment, the meningeal enhancement resolved and the cANCA titer normalized. Meningeal granulomatosis as the sole lesion in WG has never been reported in the literature. This atypical course of WG should be noted.
KW - Immunosuppression
KW - Meningitis
KW - Wegener granulomatosis
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U2 - 10.3171/jns.2002.97.5.1229
DO - 10.3171/jns.2002.97.5.1229
M3 - Article
C2 - 12450051
AN - SCOPUS:0036830616
SN - 0022-3085
VL - 97
SP - 1229
EP - 1232
JO - Journal of neurosurgery
JF - Journal of neurosurgery
IS - 5
ER -