Wisconsin card sorting test and brain perfusion imaging in early dementia

Naoya Takeda, Seishi Terada, Shuhei Sato, Hajime Honda, Hidenori Yoshida, Yuki Kishimoto, Gosuke Kamata, Etsuko Oshima, Takeshi Ishihara, Shigetoshi Kuroda

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)


Background/Aims: The presence of frontal or executive deficits in patients even at early stages of dementia is now widely recognized. We investigated the relationship between the scores of the Wisconsin card sorting test (WCST) and brain perfusion in patients with early dementia. Methods: A total of 77 subjects participated in this study. They underwent the WCST and brain single photon emission computed tomography with 99mTc-ethylcisteinate dimer. We analyzed the data using a regional cerebral blood flow (rCBF) quantification software program, 3DSRT. Results: The number of categories achieved (CA) scores of the WCST had a weakly positive correlation with regional cerebral blood flow in the bilateral precentral, bilateral callosomarginal, bilateral pericallosal, right thalamus, left central and left parietal segments. The number of perseverative errors of the Nelson type (PEN) scores had a weakly negative correlation with rCBF in the right thalamus. Conclusion: The results in this study suggest that CA scores mainly reflect the function of the precentral segments, especially the left side, and that PEN scores correlate with rCBF in the right thalamus. The results suggest that CA scores and PEN scores should be differentially estimated in the WCST.

Original languageEnglish
Pages (from-to)21-27
Number of pages7
JournalDementia and Geriatric Cognitive Disorders
Issue number1
Publication statusPublished - Feb 2010


  • 3DSRT
  • Cerebral blood flow
  • Dementia
  • Single photon emission computed tomography
  • Wisconsin card sorting test

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Cognitive Neuroscience
  • Psychiatry and Mental health


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