X-ray dark-field Imaging and potential of its clinical application

Daisuke Shimao, Hiroshi Sugiyama, Toshiyuki Kunisada, Anton Maksimenko, Fukai Toyofuku, Ei Ueno, Katsuhito Yamasaki, Chiho Obayashi, Kazuyuki Hyodo, Gang Li, Lin Pan, Xiaoming Jiang, Masami Ando

Research output: Contribution to journalConference articlepeer-review


X-ray dark-field imaging (DFI) due to refraction is under development with intension of its clinical application. In this system we have adopted an asymmetric-cut monochro-collimator (M) and an angular analyzer (A) of Si 440 diffraction at around 35 keV of X-rays. By choosing an appropriate thickness T of A that satisfies the condition T = λN where λ is the extinction distance and N integer the transmissivity in the region of |W| (angular parameter) < 1 should be theoretically almost zero and |W| > 1 should be approximately 70-80%. This has been experimentally proven. Under this condition the X-rays whose propagation direction may not change such as those receiving only absorption will not go into the forward diffraction direction after A but go into the diffraction direction, while the X-rays refracted by object may go into the forward diffraction direction after A. We have settled two targets of clinical views: soft tissues at joints and early check of breast cancer. A first clear image of articular cartilage of small joint was successfully obtained using a proximal interphalangeal joint that was amputated from a cadaver. Since larger view field is needed for clinical use the size of approximately 90 mm in square has been successfully achieved. Using this beam articular cartilage of knee and shoulder joints from the same cadaver have been successfully visualized. Further visibility test by the DFI is under way for a phantom of breast cancer, paraffin fixed sliced breast samples containing micro-calcification, tumor and excised breast tissue.

Original languageEnglish
Article number05
Pages (from-to)32-39
Number of pages8
JournalProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Issue numberI
Publication statusPublished - 2005
EventMedical Imaging 2005 - Physics of Medical Imaging - San Diego, CA, United States
Duration: Feb 13 2005Feb 15 2005


  • Analyzer
  • Articular cartilage
  • Breast cancer
  • Monochro-collimator
  • Synchrotron radiation
  • Vertical wiggler
  • X-ray dark-field imaging

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging


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