TY - JOUR
T1 - Zamamidine D, a Manzamine Alkaloid from an Okinawan Amphimedon sp. Marine Sponge
AU - Kubota, Takaaki
AU - Nakamura, Kenta
AU - Kurimoto, Shin ichiro
AU - Sakai, Kanae
AU - Fromont, Jane
AU - Gonoi, Tohru
AU - Kobayashi, Jun’ichi
N1 - Funding Information:
We thank the late Mr. Z. Nagahama for his help with sponge collection and Mr. K. Chiba, the Instrument Analysis Equipment Research Center, Showa Pharmaceutical University, for measurements of MS. This work was supported by JSPS Kakenhi grant number 25460115.
Publisher Copyright:
© 2017 The American Chemical Society and American Society of Pharmacognosy.
PY - 2017/4/28
Y1 - 2017/4/28
N2 - A new manzamine alkaloid, zamamidine D (1), was isolated from an Okinawan Amphimedon sp. marine sponge. The structure of zamamidine D (1) including the relative configuration was elucidated on the basis of spectroscopic data. Zamamidine D (1) is the first manzamine alkaloid possessing a 2,2′-methylenebistryptamine unit as the aromatic moiety instead of a β-carboline unit. Zamamidine D (1) showed antimicrobial activity against several bacteria and fungi.
AB - A new manzamine alkaloid, zamamidine D (1), was isolated from an Okinawan Amphimedon sp. marine sponge. The structure of zamamidine D (1) including the relative configuration was elucidated on the basis of spectroscopic data. Zamamidine D (1) is the first manzamine alkaloid possessing a 2,2′-methylenebistryptamine unit as the aromatic moiety instead of a β-carboline unit. Zamamidine D (1) showed antimicrobial activity against several bacteria and fungi.
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U2 - 10.1021/acs.jnatprod.6b01110
DO - 10.1021/acs.jnatprod.6b01110
M3 - Article
C2 - 28207259
AN - SCOPUS:85018405069
SN - 0163-3864
VL - 80
SP - 1196
EP - 1199
JO - Journal of Natural Products
JF - Journal of Natural Products
IS - 4
ER -
