Zamamidine D, a Manzamine Alkaloid from an Okinawan Amphimedon sp. Marine Sponge

Takaaki Kubota, Kenta Nakamura, Shin ichiro Kurimoto, Kanae Sakai, Jane Fromont, Tohru Gonoi, Jun’ichi Kobayashi

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)


A new manzamine alkaloid, zamamidine D (1), was isolated from an Okinawan Amphimedon sp. marine sponge. The structure of zamamidine D (1) including the relative configuration was elucidated on the basis of spectroscopic data. Zamamidine D (1) is the first manzamine alkaloid possessing a 2,2′-methylenebistryptamine unit as the aromatic moiety instead of a β-carboline unit. Zamamidine D (1) showed antimicrobial activity against several bacteria and fungi.

Original languageEnglish
Pages (from-to)1196-1199
Number of pages4
JournalJournal of Natural Products
Issue number4
Publication statusPublished - Apr 28 2017
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry


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