上顎臼歯抜去後の末梢性神経障害性疼痛が疑われミロガバリンが有効であった ₁ 症例

Neuropathic pain is caused by damage or diseases of the somatosensory nervous system. We report the effect of mirogabalin on chronic pain after maxillary molar extraction in a _74-year-old woman despite pregabalin, carbamazepine, and amitriptyline not having any effect. The patient began to feel contact pain in the right upper molar to anterior gingiva, the right palate, and the tongue after a maxillary molar extraction. At first, her doctor prescribed pregabalin. As this medication had no effect on her pain, so she was referred to our department for consultation. At the first consultation, no evidence suggesting the cause of the pain in the oral cavity was found. We suspected trigeminal neuralgia and prescribed carbamazepine, but her symptoms did not improve much. We then changed the medication to amitriptyline, but once again her symptoms did not improve. Next, we prescribed mirogabalin；her symptoms finally began to improve gradually, and the extent of her pain was also reduced. She has continued to take mirogabalin, and her pain remains well controlled. Furthermore, she has not experienced any side effects of mirogabalin. The present patient was suspected of having peripheral neuropathic pain caused by damage to the peripheral nerves of the superior alveolar nerve branches during a maxillary molar extraction. The efficacy of mirogabalin for the treatment of diabetic peripheral neuropathic pain and postherpetic neuralgia has been previously reported. The present case suggests that mirogabalin is also effective for peripheral neuropathic pain after tooth extraction.