糸付きクリップによる牽引補助下大腸 ESd の有効性：前向き無作為化試験（動画付き）

Background and Aim: Colorectal endoscopic submucosal dissection (ESD) remains challenging because of technical difficulties, long procedure time, and high risk of adverse events. To facilitate colorectal ESD, we developed traction-assisted colorectal ESD using a clip and thread (TAC-ESD) and conducted a randomized controlled trial to evaluate its efficacy. Methods: Patients with superficial colorectal neoplasms (SCN) ≥ 20 mm were enrolled and randomly assigned to the conventional- ESD group or to the TAC-ESD group. SCN ≤ 50 mm were treated by two intermediates, and SCN >50 mm were treated by two experts. Primary endpoint was procedure time. Secondary endpoints were TAC-ESD success rate (sustained application of the clip and thread until the end of the procedure), self-completion rate by the intermediates, and adverse events. Results: Altogether, 42 SCN were analyzed in each ESD group (conventional and TAC). Procedure time (median [range]) for the TAC-ESD group was significantly shorter than that for the conventional- ESDgroup (40 [11-86] min vs 70[30-180] min, respectively; P < 0.0001). Success rate of TAC-ESD was 95% (40/42). The intermediates self-completion rate was significantly higher for the TAC-ESD group than for the conventional-ESD group (100% [39/ 39] vs 90% [36/40], respectively; P = 0.04). Adverse events included one intraoperative perforation in the conventional-ESD group and one delayed perforation in the TAC-ESD group. Conclusion: Traction-assisted colorectal endoscopic submucosal dissection reduced the procedure time and increased the self-completion rate by the intermediates (UMIN000018612).