TY - JOUR
T1 - 12T061A and 12T061C, two new julichrome family compounds, as radical scavengers from Streptomyces sp
AU - Komoda, Toshikazu
AU - Saeki, Naoko
AU - Koseki, Yoshitaka
AU - Kiyota, Hiromasa
N1 - Publisher Copyright:
© 2016 Applied Microbiology, Molecular and Cellular Biosciences Research Foundation.
PY - 2016/2/29
Y1 - 2016/2/29
N2 - We identified two new radical scavengers, 12T061A (1, C19H20O7) and 12T061C (2, C20H22O7), from a culture of the Streptomyces sp. Spectroscopic analysis indicated that these compounds are new julichrome family compounds. Compounds 1 and 2 showed radical-scavenging activity with an ED50 of 370 μM and 18 μM, respectively. Moreover, 1 showed tumor cell growth suppressive activity in HepG2 cells, (IC50: 3.6 μM); however, no suppressive activity was shown in 2 (IC50: > 100 μM).
AB - We identified two new radical scavengers, 12T061A (1, C19H20O7) and 12T061C (2, C20H22O7), from a culture of the Streptomyces sp. Spectroscopic analysis indicated that these compounds are new julichrome family compounds. Compounds 1 and 2 showed radical-scavenging activity with an ED50 of 370 μM and 18 μM, respectively. Moreover, 1 showed tumor cell growth suppressive activity in HepG2 cells, (IC50: 3.6 μM); however, no suppressive activity was shown in 2 (IC50: > 100 μM).
KW - DPPH radical scavenger
KW - Julichrome
KW - Tumor cell growth suppressive activity
UR - https://www.scopus.com/pages/publications/84959376176
UR - https://www.scopus.com/pages/publications/84959376176#tab=citedBy
U2 - 10.2323/jgam.62.1
DO - 10.2323/jgam.62.1
M3 - Article
C2 - 26923124
AN - SCOPUS:84959376176
SN - 0022-1260
VL - 62
SP - 1
EP - 6
JO - Journal of General and Applied Microbiology
JF - Journal of General and Applied Microbiology
IS - 1
ER -