2,3-Butanedione monoxime suppresses primarily total calcium handling in canine heart

M. Maesako, J. Araki, S. Lee, Y. Doi, T. Imaoka, G. Iribe, S. Mohri, M. Hirakawa, M. Harada, H. Suga


12 被引用数 (Scopus)


Whether 2,3-butanedione monoxime (BDM, ≤5mmol/l) suppresses primarily crossbridge cycling or total Ca2+ handling in the blood-perfused whole heart remains controversial. Although BDM seems to suppress primarily total Ca2+ handling in canine hearts, more evidence is lacking. We therefore analyzed the cardiac mechanoenergetics, namely, Emax (contractility), PVA (total mechanical energy), and O2 consumption of canine BDM-treated hearts by our recently developed integrative method to assess myocardial total Ca2+ handling. This method additionally required the internal Ca2+ recirculation fraction. We obtained this from the beat constant of the exponential decay component of the postextrasystolic potentiation. Our analysis indicated significant decreases in both internal Ca2+ recirculation fraction and total Ca2+ handling in the BDM-treated heart, but virtually no change in the reactivity of Emax to total Ca2+ handling. This result corroborates the view that BDM suppresses primarily total Ca2+ handling rather than crossbridge cycling in the canine blood-perfused heart.

ジャーナルJapanese journal of physiology
出版ステータスPublished - 2000

ASJC Scopus subject areas

  • 生理学


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