A C5-derived macrophage chemotactic factor from DNP-ascaris extract-induced skin lesion in guinea pigs

M. Hirashima, Y. Hirotsu, T. Yoshimura, H. Hayashi

研究成果査読

2 被引用数 (Scopus)

抄録

In complement-depleted condition induced by cobra venom factor (CoF, tissue macrophage reaction and macrophage chemotactic activity (MCA) in skin extract from skin lesions induced by DNP-Ascaris extract (DNP-As) were decreased, respectively. MCA in the fraction containing macrophage chemotactic factor b (B fraction) was decreased completely. While MCA in the fraction containing macrophage chemotactic factor a and c (A fraction) was affected only slightly. These results suggested that the decrease of MCA of B-fraction might be associated with depletion of complement system by CoF. Using anti-C5 antibody, it was confirmed that macrophage chemotactic factor-b (MCF-b) (MW 14,000: thermostable) might be derived from C5 fragment in vivo.

本文言語English
ページ(範囲)361-367
ページ数7
ジャーナルInternational Archives of Allergy and Applied Immunology
70
4
DOI
出版ステータスPublished - 1983
外部発表はい

ASJC Scopus subject areas

  • 免疫アレルギー学

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