TY - CHAP
T1 - A Cancer Stem Cell Model
T2 - An Insight into the Conversion of Induced Pluripotent Stem Cells to Cancer Stem-Like Cells
AU - Mizutani, Akifumi
AU - Chen, Ling
AU - Kasai, Tomonari
AU - Kudoh, Takayuki
AU - Murakami, Hiroshi
AU - Fu, Li
AU - Seno, Masaharu
PY - 2014/4/14
Y1 - 2014/4/14
N2 - Appropriate model cell lines recapitulating cancer stem cell (CSC) properties would accelerate not only investigation of cancer stem cells but also development of new clinical cancer therapy by establishing a screening system for anti-cancer stem cell agents. In this chapter, the authors introduce their recent work and others to generate cells with cancer stem cell properties in vitro. They also discuss the concept of cancer stem cells with results obtained from originally established cancer stem-like cells. Finally, they describe future applications of the model to basic and clinical studies. In the field of regeneration therapy, the pluripotent stem cells such as embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) are promising sources of differentiated cells for transplantation. Interestingly, these cancer stem-like cells were not required to be introduced with the genes for cell surface markers that are commonly used to characterize and isolate cancer stem cells.
AB - Appropriate model cell lines recapitulating cancer stem cell (CSC) properties would accelerate not only investigation of cancer stem cells but also development of new clinical cancer therapy by establishing a screening system for anti-cancer stem cell agents. In this chapter, the authors introduce their recent work and others to generate cells with cancer stem cell properties in vitro. They also discuss the concept of cancer stem cells with results obtained from originally established cancer stem-like cells. Finally, they describe future applications of the model to basic and clinical studies. In the field of regeneration therapy, the pluripotent stem cells such as embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) are promising sources of differentiated cells for transplantation. Interestingly, these cancer stem-like cells were not required to be introduced with the genes for cell surface markers that are commonly used to characterize and isolate cancer stem cells.
KW - Cancer stem cell (CSC) model
KW - Cancer stem-like cells
KW - Embryonic stem cells (ESCs)
KW - Induced pluripotent stem cells
KW - Induced pluripotent stem cells (iPSCs)
KW - Regeneration therapy
UR - http://www.scopus.com/inward/record.url?scp=84926468480&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84926468480&partnerID=8YFLogxK
U2 - 10.1002/9781118356203.ch6
DO - 10.1002/9781118356203.ch6
M3 - Chapter
AN - SCOPUS:84926468480
SN - 9781118356166
VL - 9781118356166
SP - 79
EP - 87
BT - Cancer Stem Cells
PB - Wiley Blackwell
ER -
