A convergent synthesis of the right-hand fragment of ciguatoxin CTX3C

Hiroyoshi Takamura, Takashi Abe, Naoki Nishiuma, Rie Fujiwara, Takahiko Tsukeshiba, Isao Kadota

研究成果査読

13 被引用数 (Scopus)

抄録

A convergent synthesis of the right-hand fragment of ciguatoxin CTX3C was investigated. The first and second generation stereocontrolled syntheses of the LM ring fragment were achieved via spiroacetalization as a key step, respectively. The polyether framework of the HIJKLM ring fragment was constructed in a convergent manner by using intramolecular allylation, ring-closing metathesis, and stereoselective hydrogenation to form the 36-methyl substituent as the key transformations.

本文言語English
ページ(範囲)2245-2260
ページ数16
ジャーナルTetrahedron
68
10
DOI
出版ステータスPublished - 3月 11 2012

ASJC Scopus subject areas

  • 生化学
  • 創薬
  • 有機化学

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