A Japanese Patient with Gastric Cancer and Dihydropyrimidine Dehydrogenase Deficiency Presenting with DPYD Variants

Mikako Ishiguro, Ryuta Takenaka, Kenichiro Ogura, Akira Hiratsuka, Hiromasa Takeda, Daisuke Kawai, Hirofumi Tsugeno, Shigeatsu Fujiki, Hiroyuki Okada

研究成果査読

1 被引用数 (Scopus)

抄録

A 63-year-old Japanese male with stomach adenocarcinoma received oral 5-fluorouracil derivative, cisplatin and trastuzumab chemotherapy. On day 8, severe diarrhea and mucositis developed; chemotherapy was stopped. On day 14, the patient developed renal dysfunction and febrile neutropenia. He also suffered from pneumonia due to Candida albicans. Systemic symptoms improved after intensive conservative treatment. Best supportive care was continued until the patient died from gastric cancer. The dihydropyrimidine dehydrogenase protein level was low at 3.18 U/mg protein. The result of DPYD genotyping revealed three variants at positions 1615 (G>A), 1627 (A>G), and 1896 (T>C) in exons 13, 13, and 14, respectively.

本文言語English
ページ(範囲)557-562
ページ数6
ジャーナルActa medica Okayama
74
6
出版ステータスPublished - 2020

ASJC Scopus subject areas

  • 生化学、遺伝学、分子生物学一般

フィンガープリント

「A Japanese Patient with Gastric Cancer and Dihydropyrimidine Dehydrogenase Deficiency Presenting with DPYD Variants」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル