A novel leucine zipper motif-based hybrid peptide delivers a functional peptide cargo inside cells

Y. Hakata; S. Tsuchiya; H. Michiue; T. Ohtsuki; Hideki Matsui; M. Miyazawa; M. Kitamatsu

doi:10.1039/c4cc07459a

A novel leucine zipper motif-based hybrid peptide delivers a functional peptide cargo inside cells

Y. Hakata, S. Tsuchiya, H. Michiue, T. Ohtsuki, Hideki Matsui, M. Miyazawa, M. Kitamatsu

研究成果 › 査読

10 被引用数 (Scopus)

抄録

A hybrid comprising an autophagy-inducing peptide (AIP) and a cell-penetrating peptide (CPP) connected via heterodimeric leucine zippers was generated and delivered into cells. The hybrid successfully induced autophagy without significant cell death, while the same AIP directly connected to a CPP caused both autophagy and significant cell death. This journal is

本文言語	English
ページ（範囲）	413-416
ページ数	4
ジャーナル	Chemical Communications
巻	51
号	2
DOI	https://doi.org/10.1039/c4cc07459a
出版ステータス	Published - 1月 7 2015

ASJC Scopus subject areas

触媒
電子材料、光学材料、および磁性材料
セラミックおよび複合材料
化学 (全般)
表面、皮膜および薄膜
金属および合金
材料化学

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AU - Matsui, Hideki

AU - Miyazawa, M.

AU - Kitamatsu, M.

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A novel leucine zipper motif-based hybrid peptide delivers a functional peptide cargo inside cells

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