TY - JOUR
T1 - A purification system for 64Cu produced by a biomedical cyclotron for antibody PET imaging
AU - Toyota, Teruaki
AU - Hanafusa, Tadashi
AU - Oda, Takashi
AU - Koumura, Iwane
AU - Sasaki, Takanori
AU - Matsuura, Eiji
AU - Kumon, Hiromi
AU - Yano, Tsuneo
AU - Ono, Toshiro
N1 - Funding Information:
Acknowledgments We thank Mr. H. Okamoto and Mr. S. Iwasa (Central Research Laboratory, Okayama University Medical School) for atomic absorption spectrometry. We also thank Dr. T. Nagamatsu (Advanced Science Research Center, Okayama University) for excellent technical assistance and Mrs. T. Terada for preparation of the manuscript. This work was supported in part by Japan Science and Technology Agency.
PY - 2013/10
Y1 - 2013/10
N2 - Ion exchange is a simple and efficient method for separating no-carrier-added 64Cu from an irradiated Ni target. We developed a semi-automated two-round 64Cu separation system equipped with a strong-base anion exchange resin column. We first verified the efficiency of the system using a non-radioactive substitute consisting of 25 mg of Ni and 127 ng of Cu, and confirmed that Cu was completely eluted at the second round of the separation step. After the bombardment, separation of 64Cu from the Ni target was achieved with high radiochemical purity. 64Cu produced and separated in this study had an extremely low level of Ni impurity. It could be used for labeling monoclonal antibodies for antibody positron emission tomography imaging and synthesizing radiopharmaceuticals.
AB - Ion exchange is a simple and efficient method for separating no-carrier-added 64Cu from an irradiated Ni target. We developed a semi-automated two-round 64Cu separation system equipped with a strong-base anion exchange resin column. We first verified the efficiency of the system using a non-radioactive substitute consisting of 25 mg of Ni and 127 ng of Cu, and confirmed that Cu was completely eluted at the second round of the separation step. After the bombardment, separation of 64Cu from the Ni target was achieved with high radiochemical purity. 64Cu produced and separated in this study had an extremely low level of Ni impurity. It could be used for labeling monoclonal antibodies for antibody positron emission tomography imaging and synthesizing radiopharmaceuticals.
KW - Anion exchange chromatography
KW - Atomic absorption spectrometry
KW - Cyclotron
KW - Positron emission tomography (PET)
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U2 - 10.1007/s10967-012-2340-7
DO - 10.1007/s10967-012-2340-7
M3 - Article
AN - SCOPUS:84885188844
SN - 0022-4081
VL - 298
SP - 295
EP - 300
JO - Journal of Radioanalytical Chemistry
JF - Journal of Radioanalytical Chemistry
IS - 1
ER -
