Absence of mutations in the Wilms' tumor gene wt1 in de novo non-small cell lung cancers

Y. Oji; S. Miyoshi; E. Takahashi; S. Koga; Y. Nakano; Y. Shintani; H. Hirabayashi; A. Matsumura; K. Iuchi; K. Ito; Y. Kishimoto; A. Tsuboi; K. Ikegame; N. Hosen; Y. Oka; H. Ogawa; H. Maeda; S. Hayashi; I. Kawase; H. Sugiyama

Absence of mutations in the Wilms' tumor gene wt1 in de novo non-small cell lung cancers

Y. Oji, S. Miyoshi, E. Takahashi, S. Koga, Y. Nakano, Y. Shintani, H. Hirabayashi, A. Matsumura, K. Iuchi, K. Ito, Y. Kishimoto, A. Tsuboi, K. Ikegame, N. Hosen, Y. Oka, H. Ogawa, H. Maeda, S. Hayashi, I. Kawase, H. Sugiyama

大学院医歯薬学総合研究科

研究成果 › 査読

7 被引用数 (Scopus)

抄録

We recently demonstrated that the WT1 gene was overexpressed in the majority of de novo lung cancers regardless of cancer subtypes. Here, we examined WT1 genomic DNA in 38 cases of de novo non-small cell lung cancers (NSCLC) for mutations using direct sequencing. The sequencing analysis showed no mutations of WT1 genomic DNA in any of 38 de novo non-small cell lung cancers examined. These results indicated that the non-mutated, wild-type WT1 gene played an important role in de novo NSCLC.

本文言語	English
ページ（範囲）	17-20
ページ数	4
ジャーナル	Neoplasma
巻	51
号	1
出版ステータス	Published - 1月 1 2004

ASJC Scopus subject areas

癌研究

UN SDG

この成果は、次の持続可能な開発目標に貢献しています

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引用スタイル

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title = "Absence of mutations in the Wilms' tumor gene wt1 in de novo non-small cell lung cancers",

abstract = "We recently demonstrated that the WT1 gene was overexpressed in the majority of de novo lung cancers regardless of cancer subtypes. Here, we examined WT1 genomic DNA in 38 cases of de novo non-small cell lung cancers (NSCLC) for mutations using direct sequencing. The sequencing analysis showed no mutations of WT1 genomic DNA in any of 38 de novo non-small cell lung cancers examined. These results indicated that the non-mutated, wild-type WT1 gene played an important role in de novo NSCLC.",

keywords = "Mutation, Non-small cell lung cancer, The Wilms' tumor gene, WT1",

author = "Y. Oji and S. Miyoshi and E. Takahashi and S. Koga and Y. Nakano and Y. Shintani and H. Hirabayashi and A. Matsumura and K. Iuchi and K. Ito and Y. Kishimoto and A. Tsuboi and K. Ikegame and N. Hosen and Y. Oka and H. Ogawa and H. Maeda and S. Hayashi and I. Kawase and H. Sugiyama",

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T1 - Absence of mutations in the Wilms' tumor gene wt1 in de novo non-small cell lung cancers

AU - Oji, Y.

AU - Miyoshi, S.

AU - Takahashi, E.

AU - Koga, S.

AU - Nakano, Y.

AU - Shintani, Y.

AU - Hirabayashi, H.

AU - Matsumura, A.

AU - Iuchi, K.

AU - Ito, K.

AU - Kishimoto, Y.

AU - Tsuboi, A.

AU - Ikegame, K.

AU - Hosen, N.

AU - Oka, Y.

AU - Ogawa, H.

AU - Maeda, H.

AU - Hayashi, S.

AU - Kawase, I.

AU - Sugiyama, H.

PY - 2004/1/1

Y1 - 2004/1/1

N2 - We recently demonstrated that the WT1 gene was overexpressed in the majority of de novo lung cancers regardless of cancer subtypes. Here, we examined WT1 genomic DNA in 38 cases of de novo non-small cell lung cancers (NSCLC) for mutations using direct sequencing. The sequencing analysis showed no mutations of WT1 genomic DNA in any of 38 de novo non-small cell lung cancers examined. These results indicated that the non-mutated, wild-type WT1 gene played an important role in de novo NSCLC.

AB - We recently demonstrated that the WT1 gene was overexpressed in the majority of de novo lung cancers regardless of cancer subtypes. Here, we examined WT1 genomic DNA in 38 cases of de novo non-small cell lung cancers (NSCLC) for mutations using direct sequencing. The sequencing analysis showed no mutations of WT1 genomic DNA in any of 38 de novo non-small cell lung cancers examined. These results indicated that the non-mutated, wild-type WT1 gene played an important role in de novo NSCLC.

KW - Mutation

KW - Non-small cell lung cancer

KW - The Wilms' tumor gene

KW - WT1

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Absence of mutations in the Wilms' tumor gene wt1 in de novo non-small cell lung cancers

抄録

ASJC Scopus subject areas

UN SDG

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