Accumulation of Clostridium perfringens epsilon-toxin in the mouse kidney and its possible biological significance

Eiji Tamai, Tetsuya Ishida, Shigeru Miyata, Osamu Matsushita, Hirofumi Suda, Shoji Kobayashi, Hiroshi Sonobe, Akinobu Okabe

研究成果査読

51 被引用数 (Scopus)

抄録

In this paper we show that Clostridium perfringens epsilon-toxin accumulates predominantly in the mouse kidney, where it is distributed mainly in glomeruli, capillaries, and collecting ducts. Although some pycnotic and exfoliated epithelial cells were observed in distal tubuli and collecting ducts, there were no findings indicative of severe renal injury. Bilateral nephrectomy increased the mouse lethality of the toxin, suggesting that the kidney contributes to the host defense against the lethal toxicity of epsilon-toxin.

本文言語English
ページ(範囲)5371-5375
ページ数5
ジャーナルInfection and Immunity
71
9
DOI
出版ステータスPublished - 9月 1 2003
外部発表はい

ASJC Scopus subject areas

  • 寄生虫科
  • 微生物学
  • 免疫学
  • 感染症

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