Activity of nucleotide excision repair enzymes for oxanine cross-link lesions.

Toshiaki Nakano, Atsushi Katafuchi, Hiroaki Terato, Toshinori Suzuki, Bennett Van Houten, Hiroshi Ide

研究成果査読

8 被引用数 (Scopus)

抄録

Nitric oxide and nitrous acid induce deamination of DNA bases, resulting in uracil, hypoxanthine, xanthine, and oxanine (Oxa) as major damage. Oxa reacts further with polyamines and DNA binding proteins, generating bulky cross-link adducts. Recently we have shown Oxa and cross-link adducts are potentially genotoxic lesions. In the present study, we have assessed the role of base excision repair (BER) and nucleotide excision repair (NER) systems in the repair of Oxa and Oxa-spermine (Oxa-Sp) cross-link adducts. Oxa was very poorly removed from DNA by both BER glycosylases and NER enzymes, whereas Oxa-Sp was efficiently excised by E. coli and human NER enzymes.

本文言語English
ページ(範囲)293-294
ページ数2
ジャーナルNucleic acids symposium series (2004)
49
DOI
出版ステータスPublished - 2005
外部発表はい

ASJC Scopus subject areas

  • 医学一般

フィンガープリント

「Activity of nucleotide excision repair enzymes for oxanine cross-link lesions.」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル