抄録
Lonidamine, a unique new type of anticancer agent has been shown to exert marginal activity in patients with resistant small cell lung cancer. We have assessed cytotoxic activity using seven human small cell lung cancer cell lines and the drug resistant small cell lung cancer sublines, Adriamycin-resistant SBC-3/ ADM100, etoposide-resistant SBC-3/ETP and cisplatin-resistant SBC-3/CDDP. Although lonidamine had only a minimal activity in seven human small cell lung cancer cell lines, SBC-3/ADM100 cells were more sensitive to lonidamine than the parent SBC-3 cells to a 1.6-fold extent in terms of IC50. SBC-3/CDDP and SBC-3/ ETP had no cross-resistance to lonidamine at all. These observations may be of potential clinical significance in treating small cell lung cancer.
| 本文言語 | English |
|---|---|
| ページ（範囲） | 463-470 |
| ページ数 | 8 |
| ジャーナル | Anti-Cancer Drug Design |
| 巻 | 7 |
| 号 | 6 |
| 出版ステータス | Published - 12月 1 1992 |
ASJC Scopus subject areas
- 生化学
- 腫瘍学
- 生化学、遺伝学、分子生物学（全般）
- 薬理学
- 創薬
- 有機化学
UN SDG
この成果は、次の持続可能な開発目標に貢献しています
