TY - JOUR
T1 - Application of a numerical simulation to improve the separation efficiency of a sperm sorter
AU - Hyakutake, Toru
AU - Hashimoto, Yuki
AU - Yanase, Shinichiro
AU - Matsuura, Koji
AU - Naruse, Keiji
PY - 2009
Y1 - 2009
N2 - This paper describes a study in which numerical simulations were applied to improve the separation efficiency of a microfluidic-based sperm sorter. Initially, the motion of 31 sperm were modeled as a sinusoidal wave. The modeled sperm were expected to move while vibrating in the fluid within the microchannel. In this analysis, the number of sperm extracted at the outlet channel and the rate of movement of the highly motile sperm were obtained for a wide range of flow velocities within the microchannel. By varying the channel height, and the width and the position of the sperm-inlet channel, we confirmed that the separation efficiency was highly dependent on the fluid velocity within the channel. These results will be valuable for improving the device configuration, and might help to realize further improvements in efficiency in the future.
AB - This paper describes a study in which numerical simulations were applied to improve the separation efficiency of a microfluidic-based sperm sorter. Initially, the motion of 31 sperm were modeled as a sinusoidal wave. The modeled sperm were expected to move while vibrating in the fluid within the microchannel. In this analysis, the number of sperm extracted at the outlet channel and the rate of movement of the highly motile sperm were obtained for a wide range of flow velocities within the microchannel. By varying the channel height, and the width and the position of the sperm-inlet channel, we confirmed that the separation efficiency was highly dependent on the fluid velocity within the channel. These results will be valuable for improving the device configuration, and might help to realize further improvements in efficiency in the future.
KW - Human reproduction
KW - Microfluid
KW - Numerical simulation
KW - Separation efficiency
KW - Sperm sorter
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U2 - 10.1007/s10544-008-9207-2
DO - 10.1007/s10544-008-9207-2
M3 - Article
C2 - 18815887
AN - SCOPUS:59949098187
SN - 1387-2176
VL - 11
SP - 25
EP - 33
JO - Biomedical Microdevices
JF - Biomedical Microdevices
IS - 1
ER -