Associations of serum β-carotene and retinol concentrations with insulin resistance: The Toon Health Study

Kana Higuchi, Isao Saito, Koutatsu Maruyama, Eri Eguchi, Hiromi Mori, Sakurako Tanno, Susumu Sakurai, Taro Kishida, Wataru Nishida, Haruhiko Osawa, Takeshi Tanigawa

研究成果査読

28 被引用数 (Scopus)

抄録

Objective: Although green and yellow vegetables have beneficial effects against type 2 diabetes, the relationship of their nutritive content with insulin resistance is poorly understood. The aim of this study was to examine the associations of serum β-carotene and retinol concentrations with glucose and insulin concentrations. Methods: We recruited 951 Japanese men and women ages 30 to 79 y who were not undergoing treatment for diabetes and measured their serum β-carotene and retinol concentrations. A 75-g oral glucose tolerance test was performed and the homeostasis model assessment for insulin resistance (HOMA-IR) and the Matsuda Index were calculated as measures of insulin resistance. Several confounding factors were adjusted for with multivariable logistic models. Results: Multivariable-adjusted odds ratios of the highest quartile of serum β-carotene compared with the lowest quartile for HOMA-IR >1.6 and Matsuda Index <4.9 were 0.56 (95% confidence interval, 0.34-0.94) and 0.62 (0.37-1.02), respectively. When stratified by sex and overweight status, these associations were observed for women and non-overweight individuals. Serum retinol concentration was not associated with either index. Furthermore, according to the nutritional survey, serum β-carotene concentration was associated with green and yellow vegetable intake (P = 0.01). Conclusion: Our findings suggest that higher serum β-carotene levels, associated with higher intake of green and yellow vegetables, confer beneficial effects against insulin resistance.

本文言語English
ページ(範囲)975-980
ページ数6
ジャーナルNutrition
31
7-8
DOI
出版ステータスPublished - 2015

ASJC Scopus subject areas

  • 内分泌学、糖尿病および代謝内科学
  • 栄養および糖尿病

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