Benefit of prednisolone alone in nodal peripheral T-cell lymphoma with T follicular helper phenotype

Wataru Kitamura, Hiroki Kobayashi, Tomohiro Urata, Yumiko Sato, Yusuke Naoi, Tadashi Yoshino, Yoshinobu Maeda, Shoichi Kuyama

研究成果査読

1 被引用数 (Scopus)

抄録

A 71-year-old Japanese man presented with severe thrombocytopenia. A whole-body CT at presentation showed small cervi-cal, axillary, and para-aortic lymphadenopathy, leading to suspicion of immune thrombocytopenia due to lymphoma. Biopsy was difficult to perform because of severe thrombocytopenia. Thus, he received prednisolone (PSL) therapy and his platelet count gradually recovered. Two and a half years after PSL therapy initiation, his cervical lymphadenopathy slightly progressed without other clinical symptoms. Hence, a biopsy from the left cervical lymph node was performed, and he was diagnosed with nodal peripheral T-cell lymphoma (PTCL) with T follicular helper (TFH) phenotype. Due to various complications, we continued treatment with prednisolone alone after the diagnosis of lymphoma; however, there was no further increase in lymph node enlargement and no other lymphoma-related symptoms for one and a half years after diagnosis. Although immunosup-pressive therapy has been reported to produce a response in some patients with angioimmunoblastic T-cell lymphoma, our experience suggests that a similar subset may exist in patients with nodal PTCL with TFH phenotype, which has the same cellular origin. Immunosuppressive therapies may constitute an alternative treatment option even in the era of novel molecular-targeted therapies, especially for elderly patients who are ineligible for chemotherapy.

本文言語English
ページ(範囲)37-42
ページ数6
ジャーナルJournal of Clinical and Experimental Hematopathology
63
1
DOI
出版ステータスPublished - 2023

ASJC Scopus subject areas

  • 医学一般

フィンガープリント

「Benefit of prednisolone alone in nodal peripheral T-cell lymphoma with T follicular helper phenotype」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル