BRPK, a novel protein kinase showing increased expression in mouse cancer cell lines with higher metastatic potential

Akinori Nakajima; Ken Kataoka; Mei Hong; Masakiyo Sakaguchi; Nam Ho Huh

doi:10.1016/S0304-3835(03)00443-9

BRPK, a novel protein kinase showing increased expression in mouse cancer cell lines with higher metastatic potential

Akinori Nakajima
, Ken Kataoka
, Mei Hong
, Masakiyo Sakaguchi
, Nam Ho Huh

研究成果 › 査読

61 被引用数 (Scopus)

抄録

A novel protein kinase named BRPK was isolated and partially characterized. BRPK was expressed at a higher level in three carcinoma cell lines with higher metastatic potential. Mouse and human BRPK cDNAs are well conserved and encode 580 and 581 amino acids, respectively. BRPK has a serine/threonine-type protein kinase domain, and the recombinant proteins of BRPK were capable of autophosphorylation. The results of a comparative sequence analysis indicated a possible link of BRPK to BRAP2. BRAP2 is known to bind the nuclear localization signal of BRCA1. We cloned mouse BRAP2 cDNA and showed the presence of isoforms.

本文言語	English
ページ（範囲）	195-201
ページ数	7
ジャーナル	Cancer Letters
巻	201
号	2
DOI	https://doi.org/10.1016/S0304-3835(03)00443-9
出版ステータス	Published - 11月 14 2003

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この成果は、次の持続可能な開発目標に貢献しています

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ASJC Scopus subject areas

腫瘍学
癌研究

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10.1016/S0304-3835(03)00443-9

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title = "BRPK, a novel protein kinase showing increased expression in mouse cancer cell lines with higher metastatic potential",

abstract = "A novel protein kinase named BRPK was isolated and partially characterized. BRPK was expressed at a higher level in three carcinoma cell lines with higher metastatic potential. Mouse and human BRPK cDNAs are well conserved and encode 580 and 581 amino acids, respectively. BRPK has a serine/threonine-type protein kinase domain, and the recombinant proteins of BRPK were capable of autophosphorylation. The results of a comparative sequence analysis indicated a possible link of BRPK to BRAP2. BRAP2 is known to bind the nuclear localization signal of BRCA1. We cloned mouse BRAP2 cDNA and showed the presence of isoforms.",

keywords = "BRAP2, BRCA1, Metastasis, Protein kinase",

author = "Akinori Nakajima and Ken Kataoka and Mei Hong and Masakiyo Sakaguchi and Huh, \{Nam Ho\}",

note = "Funding Information: This work was supported by a Grant-in-Aid from the Ministry of Education, Culture, Sports, Science and Technology of Japan. We are grateful to Dr Mikiro Takaishi for his technical help and valuable discussion.",

year = "2003",

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doi = "10.1016/S0304-3835(03)00443-9",

language = "English",

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journal = "Cancer Letters",

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TY - JOUR

T1 - BRPK, a novel protein kinase showing increased expression in mouse cancer cell lines with higher metastatic potential

AU - Nakajima, Akinori

AU - Kataoka, Ken

AU - Hong, Mei

AU - Sakaguchi, Masakiyo

AU - Huh, Nam Ho

N1 - Funding Information: This work was supported by a Grant-in-Aid from the Ministry of Education, Culture, Sports, Science and Technology of Japan. We are grateful to Dr Mikiro Takaishi for his technical help and valuable discussion.

PY - 2003/11/14

Y1 - 2003/11/14

N2 - A novel protein kinase named BRPK was isolated and partially characterized. BRPK was expressed at a higher level in three carcinoma cell lines with higher metastatic potential. Mouse and human BRPK cDNAs are well conserved and encode 580 and 581 amino acids, respectively. BRPK has a serine/threonine-type protein kinase domain, and the recombinant proteins of BRPK were capable of autophosphorylation. The results of a comparative sequence analysis indicated a possible link of BRPK to BRAP2. BRAP2 is known to bind the nuclear localization signal of BRCA1. We cloned mouse BRAP2 cDNA and showed the presence of isoforms.

AB - A novel protein kinase named BRPK was isolated and partially characterized. BRPK was expressed at a higher level in three carcinoma cell lines with higher metastatic potential. Mouse and human BRPK cDNAs are well conserved and encode 580 and 581 amino acids, respectively. BRPK has a serine/threonine-type protein kinase domain, and the recombinant proteins of BRPK were capable of autophosphorylation. The results of a comparative sequence analysis indicated a possible link of BRPK to BRAP2. BRAP2 is known to bind the nuclear localization signal of BRCA1. We cloned mouse BRAP2 cDNA and showed the presence of isoforms.

KW - BRAP2

KW - BRCA1

KW - Metastasis

KW - Protein kinase

UR - https://www.scopus.com/pages/publications/0242321145

UR - https://www.scopus.com/pages/publications/0242321145#tab=citedBy

U2 - 10.1016/S0304-3835(03)00443-9

DO - 10.1016/S0304-3835(03)00443-9

M3 - Article

C2 - 14607334

AN - SCOPUS:0242321145

SN - 0304-3835

VL - 201

SP - 195

EP - 201

JO - Cancer Letters

JF - Cancer Letters

IS - 2

ER -

BRPK, a novel protein kinase showing increased expression in mouse cancer cell lines with higher metastatic potential

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