CD204-Positive tumor-associated macrophages relate to malignant transformation of colorectal adenoma

Daiki Taniyama, Kiyomi Taniyama, Kazuya Kuraoka, Hideki Yamamoto, Junichi Zaitsu, Akihisa Saito, Naoya Sakamoto, Kazuhiro Sentani, Naohide Oue, Wataru Yasui

研究成果査読

11 被引用数 (Scopus)

抄録

Background/Aim: Colorectal adenoma is well known as a precursor lesion of colorectal adenocarcinoma (ADC). We recently reported the significance of CD204 (+) tumor-associated macrophages (TAMs), a vital component of the tumor microenvironment, in the carcinoma development of gastric adenoma. The aim of the present study was to clarify the roles of TAM in the malignant transformation of colorectal adenoma. Materials and Methods: We immunohistochemically assessed the TAM number in 88 tubular or tubulovillous adenomas that were classified into L (low-grade adenomas) or H (high-grade adenomas). Results: Larger adenoma size, higher frequency of villous structure, loss of proliferation polarity, p53 expression, larger TAM numbers and larger microvessel density (MVD) were detected in Group H than in Group L adenomas. Positive relations were observed between TAM and MVD, proliferation polarity and the expression of p53. Conclusion: CD204 (+) TAM is a novel component in the malignant transformation of colorectal adenoma.

本文言語English
ページ(範囲)2767-2775
ページ数9
ジャーナルAnticancer research
39
6
DOI
出版ステータスPublished - 2019
外部発表はい

ASJC Scopus subject areas

  • 腫瘍学
  • 癌研究

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