Cell-based biological pacemakers: Progress and problems

研究成果査読

11 被引用数 (Scopus)

抄録

The number of permanent pacemaker implantations has been increasing due to the aging of populations worldwide and the increase in the numbers of patients with heart diseases. Commercially available mechanical pacemakers are very useful but still have some problems including short battery life, a risk of infection, the absence of physiological autonomic responsiveness, metal allergy, and electronic interference. A biological pacemaker may resolve these problems and regenerate the cardiac pacemaker. Cell-based therapy and gene therapy have been addressed with the goal of solving the challenges of biological pacemaker. However, the clinical application of a biological pacemaker has not yet been realized. Here we discuss the types of cells that can be used for a biological pacemaker and the problems that remain regarding the clinical applications of cell-based therapy.

本文言語English
ページ(範囲)1-7
ページ数7
ジャーナルActa medica Okayama
72
1
出版ステータスPublished - 2018

ASJC Scopus subject areas

  • 生化学、遺伝学、分子生物学一般

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